Difference between revisions of "2017 Winter Project Week/LORDWI"

From NAMIC Wiki
Jump to: navigation, search
Line 23: Line 23:
 
|
 
|
 
<!-- Objective bullet points -->
 
<!-- Objective bullet points -->
* Evaluate/validate the density-based registration framework for DWI developed at UCPH (this is a nonrigid model - see the link below for a paper on the global algorithm).
+
* Objective: Evaluate/validate a density-based non-rigid registration framework for DWI (see the link below for a paper on similarity measure used).
 +
* Short description: The model is based on Free-Form Deformation B-splines where the directions are updated using the normalized Jacobian. B-spline interpolation is used spatially, the Watson Distribution is used directionally. Histogram is built smoothed. Similarity is NMI and optimisation is L-BFGS.
 
|
 
|
 
<!-- Approach and Plan bullet points -->
 
<!-- Approach and Plan bullet points -->

Revision as of 00:22, 9 January 2017

Home < 2017 Winter Project Week < LORDWI

Key Investigators

  • Henrik Groenholt Jensen, UCPH
  • Lauren J. O'Donnell, BWH
  • Tina Kapur, BWH
  • Fan Zhang, BWH
  • Carl-Fredrik Westin, BWH

Project Description

Objective Approach and Plan Progress and Next Steps
  • Objective: Evaluate/validate a density-based non-rigid registration framework for DWI (see the link below for a paper on similarity measure used).
  • Short description: The model is based on Free-Form Deformation B-splines where the directions are updated using the normalized Jacobian. B-spline interpolation is used spatially, the Watson Distribution is used directionally. Histogram is built smoothed. Similarity is NMI and optimisation is L-BFGS.
  • Figure out what diffusion data is available (preferably data already evaluated by another registration model).
  • Discuss best ways to validate results (tractography, biomarkers, synthetic data, phantoms, others?). So far we have visually tested inter-subject registrations of HCP data and intra-subject multi-shell, and intra-subject on young brain tumor subjects.
  • Consider if Slicer can be used in tandem for evaluation.
  • This method introduces Mutual Information to nonrigid registration of DWI. Discuss if other similarity measures (e.g. correlation measures) would be better suited for specific problems.

Background and References