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===Key Investigators===
*Nikos Chrisochoides, CRTC (Project lead)
*Andrey Fedorov, CRTC
*Luis Ibanez, Kitware
*Jim Miller, Kitware
*Dan Marcus
*Tina Kapur
*Marcel Prastawa

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<h1>Objective</h1>
The mission of the Center for Real-Time Computing is to promote innovation in time critical applications like medical image analysis for Image Guided Therapy. The application of our focus is non-rigid image registration (NRR) for image-guided neurosurgery. The objective is to improve the performance, accuracy and usability of the existing method. There are two sub-projects we plan to explore.

1. Distributed parametric search for optimum parameter setting during NRR. This project includes three components: 1) development/evaluation of tools and methods for automated registration validation; 2) collection of ground truth data sets; 3) development of the high performance computing infrastructure.

2. Tetrahedral mesh generation for intra-cranial cavity discretization used in physics-based NRR.

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<h1>Approach, Plan</h1>

1. Distributed parametric search:

* need help with automated validation approaches, neurosurgery datasets

* evaluate the infrastructure options: GWE/GSlicer3? web portal? TeraGrid?

* are there other needs for this kind of large-scale computing?

2. Tetrahedral mesh generation:

* meshing TCON Jun 19: no volume mesh generation discussed. What is (is there?) the need for tetrahedral mesh generation from NA-MIC projects?

* status of unstructured grid visualization in Slicer3

* meshing as a plugin in Slicer3

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<h1>Progress</h1>
1. Distributed parameter search for NRR:

* missing features in GWE: support for MPI process execution and flow (dependencies) control

* work in progress: scripts for remote submission and execution on TeraGrid (execution module integration of the front end for registration with Slicer complete earlier)

* new datasets for registration evaluation: MRT data from XNAT, tumor growth for NRR validation (Utah)

2 (Tetrahedral) mesh generation:

* very limited open source support, limited mesh generation functionality in ITK/VTK

* identified a group of applications that require meshing, continue discussion

* Slicer3 meshing integration: vtkUnstructuredGrid support almost ready in Slicer


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===Funding===
This work is supported in part by NSF grant CSI-719929 and by John Simon Guggenheim Memorial Foundation.

===References===
* [http://crtc.wm.edu CRTC web site: ]