View source for 2013 Winter Project Week:Hybrid registration

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==Key Investigators==
* Nadya Shusharina, Greg Sharp, MGH 
* Steve Pieper, Isomics



We propose to augment B-spline deformable registration with landmark information. Matching of landmarks is performed by the optimization procedure applied to the cost function containing an intensity-based data term and two constraints, smoothing and an explicit landmark matching. 

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<h3>Objective</h3>
* To develop the method to extend automatic algorithm of deformable image registration based on B-spline approximation
* The method includes landmark matching in the form of explicit landmark constraint
* The method is relevant for fast registrations that require matching of certain image features
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<h3>Approach, Plan</h3>
* To introduce CLI in Slicer 4 as a part of Plastimatch Registration module
* Try the algorithm on various data sets
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<h3>Progress</h3>
We extended Plastimatch B-spline deformable registration module with landmark matching functionality. We tested the new feature on synthetic image and obtained satisfactory results. We set future goal to work on interactive real-time landmark placing. 
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