View source for DBP: Andy Saykin visit BWH and MIT April 21

'''PRESENT'''<nowiki>: Andy Saykin, Martha Shenton, Sonia Pujol, C-F Westin, Sandy Wells, Mark Dreusicke </nowiki>

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'''Topics Discussed:'''

<br />'''Slicer Workshop at Dartmouth, May 26th and 27th'''

* Sonia is organizing the material that will be covered at the workshop
* Dr. Saykin would like an introductory overview of Slicer’s capabilities
** Emphasis should be placed on structural analysis (labelmap drawing, etc.)
** Overview of DTI capabilities should be briefly covered as well
* Specific issues of concern include:
** I/O file format, i.e., making sure current data at Dartmouth can be read (analyze format)
** comparing BWH "pipeline" processing protocols with Dartmouth protocols (automatic segmentation, etc.)
* '''Note for Dartmouth researchers:''' Click [https://www.slicer.org/wiki/Slicer:Slicer2.4_Getting_Started here] for instructions on getting started with Slicer

<br />'''Implementation plans for fMRI tasks at the BWH site'''

* BWH should imitate the Dartmouth processing sequence
* Marek Kubicki will be in touch Dr. Saykin, with the goal of having the fMRI sequence up and running at BWH by the end of June
* Initial test cases should be scanned at BWH and sent to Dartmouth for analysis, to ensure software/acquisition compatibility
* Testing protocols will need to be developed (similar to test datasets used by BIRN and ADNI)
* More specific details will be discussed at a future meeting (see below)

<br />'''DTI acquisition sequences'''

* Dartmouth is expecting to have a new scanner in the fall
* Both BWH and Dartmouth will be updating their acquisition protocols (using parallel imaging, etc.) to obtain higher resolution data
* Details on updating DTI procedures also will be discussed at a future meeting (see below)

<br />'''Analytic strategies for integrating structural connectivity and functional connectivity'''

* Connectivity analyses will depend on close collaboration between sites to determine technical aspects of acquisition and coregistration of images
* For now, both sites should keep in mind their technical procedures when analyzing structural, DTI, and fMRI images, so that the "nuts and bolts" can be discussed later

<br />'''Overlap and differences in clinical and neurocognitive measures being obtained'''

* BWH/Harvard and Dartmouth appear to be using the same clinical measures (DSM IV diagnosis, CVLT, etc.)
* Each center will look into the medication equivalents used

<br />'''Outstanding IRB issues'''

* Marty will incorporate Dr. Saykin’s fMRI protocols into the IRB for U54

<br />'''Potential recruitment from Dartmouth for Sandy Wells' PhD candidate student'''

* Eric Cosman is a PhD student working with Sandy Wells on multivariate autoregressive modeling
** This modeling may be used to study connectivity differences in populations
* Dr. Saykin will follow up with Dr. Wells on the possibility of a collaboration, using patient/normal populations from Dartmouth

<br />'''FUTURE MEETINGS'''

* Future meetings will be held to further discuss these issues
* The possibility of a morning/afternoon session was discussed, with a date TBA
* Issues to be discussed include:
** fMRI processing at BWH
** Incorporating LSDI scanning at Dartmouth
** The future of DTI at both test centers (pulse sequence, acquisition, etc.)
* These meetings should include the following people:
** Marek Kubicki
** C-F Westin
** Stephan Maier
** Dave Tuck
** Sandy Wells
** Martha Shenton
** Andy Saykin
** Konstantinos Arfanakis