NA-MIC Brains Collaboration

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Abstract

This project is not an NCBC collaboration grant, but instead a Continued Development and Maintenance of Software grant. The intent of this application is to update the BRAINS image analysis software developed at the University of Iowa.

Grant #

1R01NS050568

Key Personnel

The collaborators include Vincent Magnotta, Hans Johnson, Jeremy Bockholt, and Nancy Andreasen.

Projects

There are three main thrusts of this application as outlined below.

Implement an Automated Brain Analysis Pipeline

• BRAINS Automated Pipeline
• Support for Batch Processing
• Visual Review and Verification of Results

Code Refactoring for Cross Platform Support

• Refactor Current Modules using ITK and VTK
• Build GUI using Slicer3 Interface
• Use Python as Scripting Language

Validation of Pipeline Using MIND MCIC Sample

• Evaluate MIND MCIC Human Phantom Sample Using Automated Pipeline
• Evaluate Differences between Patients with Schizophrenia and Normal Controls using Automated Pipeline

BRAINS Features

• BRAINS Gallery
• 

  BRAINS Surface showing cortical depth

• 

  BRAINS Surface showing curvature (ie sulcal and gyral labels)

• 

  BRAINS Continuous Tissue Classification

• 

  Automated segmentation of Subcortical nuclei using Neural Networks

• BRAINS-Image-Registration

  BRAINS Image Registration using ITK Mutual Information

Publications

1. Powell S, Magnotta VA, Johnson H, Jammalamadaka VK, Pierson R, Andreasen NC. Registration and machine learning-based automated segmentation of subcortical and cerebellar brain structures. Neuroimage. 2007 Aug 22; [Epub ahead of print].