Difference between revisions of "Projects:FractionalAnisotropyOfTheCorpusCallosumAndAnteriorCommissure"
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= Fractional Anisotropy of the Corpus Callosum and Anterior Commissure = | = Fractional Anisotropy of the Corpus Callosum and Anterior Commissure = | ||
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To use DTI to quantify the integrity of interhemispheric connectivity in schizophrenic patients, by measuring fractional anisotropy (FA) and other diffusion measures in both corpus collosum (CC) and anterior commissure (AC) fibers. To the best of our knowledge, no previous study has analyzed diffusion measures along the anterior commissure. | To use DTI to quantify the integrity of interhemispheric connectivity in schizophrenic patients, by measuring fractional anisotropy (FA) and other diffusion measures in both corpus collosum (CC) and anterior commissure (AC) fibers. To the best of our knowledge, no previous study has analyzed diffusion measures along the anterior commissure. | ||
| − | + | = Description = | |
We have implemented a scanning protocol by which we obtain several midline sagittal slices, allowing high resolution data of both the midsagittal corpus callosum and the anterior commisure. Preliminary results (methods currently being improved) indicate decreased FA in the midsagittal corpus callosum in schizophrenics, and decreased overall diffusivity in both the corpus callosum and anterior commisure. We are currently utilizing fiber tracking in these structures to calculate FA (and other diffusion measures) along both CC and AC fibers. We are considering using smoothed data to create these fibers. We are also using automatic clustering to separate anatomically similar fibers, and compare diffusion measures along fibers extending to different brain regions. | We have implemented a scanning protocol by which we obtain several midline sagittal slices, allowing high resolution data of both the midsagittal corpus callosum and the anterior commisure. Preliminary results (methods currently being improved) indicate decreased FA in the midsagittal corpus callosum in schizophrenics, and decreased overall diffusivity in both the corpus callosum and anterior commisure. We are currently utilizing fiber tracking in these structures to calculate FA (and other diffusion measures) along both CC and AC fibers. We are considering using smoothed data to create these fibers. We are also using automatic clustering to separate anatomically similar fibers, and compare diffusion measures along fibers extending to different brain regions. | ||
| − | + | = Key Investigators = | |
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* BWH: Marek Kubicki, Carl-Fredrik Westin, Mark Dreusicke, Doug Markant, Martha Shenton | * BWH: Marek Kubicki, Carl-Fredrik Westin, Mark Dreusicke, Doug Markant, Martha Shenton | ||
* MIT: Lauren O'Donnell | * MIT: Lauren O'Donnell | ||
| − | + | = Links = | |
* Progress on improving the method used to create corpus callosum ROIs [[DBP:Harvard:Software:Bugs:Corpus_Callosum|'''here''']]. | * Progress on improving the method used to create corpus callosum ROIs [[DBP:Harvard:Software:Bugs:Corpus_Callosum|'''here''']]. | ||
* Images of corpus callosum fibers using smoothed vs. unsmoothed data [[DBP:Harvard:Software:Bugs:Corpus_Callosum_Fibers|'''here''']]. | * Images of corpus callosum fibers using smoothed vs. unsmoothed data [[DBP:Harvard:Software:Bugs:Corpus_Callosum_Fibers|'''here''']]. | ||
Latest revision as of 16:41, 12 December 2007
Home < Projects:FractionalAnisotropyOfTheCorpusCallosumAndAnteriorCommissureBack to NA-MIC_Collaborations, MIT Algorithms
Fractional Anisotropy of the Corpus Callosum and Anterior Commissure
To use DTI to quantify the integrity of interhemispheric connectivity in schizophrenic patients, by measuring fractional anisotropy (FA) and other diffusion measures in both corpus collosum (CC) and anterior commissure (AC) fibers. To the best of our knowledge, no previous study has analyzed diffusion measures along the anterior commissure.
Description
We have implemented a scanning protocol by which we obtain several midline sagittal slices, allowing high resolution data of both the midsagittal corpus callosum and the anterior commisure. Preliminary results (methods currently being improved) indicate decreased FA in the midsagittal corpus callosum in schizophrenics, and decreased overall diffusivity in both the corpus callosum and anterior commisure. We are currently utilizing fiber tracking in these structures to calculate FA (and other diffusion measures) along both CC and AC fibers. We are considering using smoothed data to create these fibers. We are also using automatic clustering to separate anatomically similar fibers, and compare diffusion measures along fibers extending to different brain regions.
Key Investigators
- BWH: Marek Kubicki, Carl-Fredrik Westin, Mark Dreusicke, Doug Markant, Martha Shenton
- MIT: Lauren O'Donnell
