Projects:AttentionalCircuitsInSchizophreniaInfMRIAndPET

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Attentional Circuits in Schizophrenial InfMRIA and Pet

Our objective is to use structural equation modeling to compare attentional circuitry within the legacy set of 28 schizophrenic subjects who performed similar attentional tasks in both a PET and fMRI scan.

Description

The data have been analyzed and segmented into a Talairach-based analysis. The mean glucose metabolism has been measured in the PET data on a region by region basis and the mean contrast values in the same regions have been measured in the fMRI data. A structural equation model is being defined for comparison among the two datasets. However, the segmentations are crude at best, and once the methods have been implemented on these regions, a second analysis using the improved segmentation methods will be implemented using FreeSurfer derived segmentations.

Key Investigators

• UCI: David Keator, Jessica Turner, James Fallon, Steven Potkin, David Medina-Fuentes

Links

• The data can be found via the NAMIC website: http://www.na-mic.org/Wiki/index.php/DataRepository#UCI_Structural.2C_Functional_and_PET_Images.2C_Genetic_and_Clinical_Data