Difference between revisions of "NA"

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  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
 
  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
  
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'''Objective:''' To quantify changes in diffusion properties along the cingulum bundle for schizophrenics and normal controls.
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'''Objective:''' To develop methodology that will permit investigators to specify functional MRI regional of interests (fROI) and determine the optimal white matter pathways between the fROIs based on DTI.
  
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'''Progress:''' We improved the diffusion MRI module in slicer to allow for a better fiber selection (based on multiple regions of interest) as well as fiber clustering. We set up a processing pipeline to allow for statistical computations of fiber diffusion properties across the fibers of a fiber bundle and along the bundle itself. Further, we are in the process of developing a continuous representation of fiber bundles (see Figure) to allow for a more geometric computation of bundle diffusion quantities.
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'''Progress:''' Working path of interest tool at Dartmouth that is currently being tested further. We've had success on mapping out uncinate fasciculus and arcuate fasciculus in a healthy adult. Next step will be to apply the methodology in a larger sample of subjects to verify reliability within and across subjects.
  
 
'''Key Investigators:'''
 
'''Key Investigators:'''
  
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* Harvard PNL: Marc Niethammer, Sylvain Bouix, Marek Kubicki, Mark Dreusicke, Martha Shenton
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* Dartmouth: Andrew Saykin, John West, Robert Roth, Laura Flashman
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* MIT: CF Westin, Lauren O'Donnell, Raul San Jose
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* Harvard: Dave Tuch, Josh Snyder, Steve Pieper, Gordon Kindlmann
  
 
'''Links:'''
 
'''Links:'''
  
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* [[DBP:Harvard:Collaboration:MITDTI|DBP:Harvard:Collaboration:MITDTI]]
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* [[AHM_2006:ProjectsDTIPathOfInterest|Path of Interest Algorithm Development]]
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* http://pnl.bwh.harvard.edu/index.html
 
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'''Representative Image and Descriptive Caption:'''
 
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<div class="thumb tleft"><div style="width: 402px">[[Image:Cingulum_reseeded_withtrajectories.png|[[Image:400px-Cingulum_reseeded_withtrajectories.png|Cingulum bundle with arclength parameterization.]]]]<div class="thumbcaption"><div class="magnify" style="float: right">[[Image:Cingulum_reseeded_withtrajectories.png|[[Image:magnify-clip.png|Enlarge]]]]</div>Cingulum bundle with arclength parameterization.</div></div></div>
 

Revision as of 14:03, 18 December 2006

Home < NA
Back to NA-MIC_Collaborations

Objective: To develop methodology that will permit investigators to specify functional MRI regional of interests (fROI) and determine the optimal white matter pathways between the fROIs based on DTI.

Progress: Working path of interest tool at Dartmouth that is currently being tested further. We've had success on mapping out uncinate fasciculus and arcuate fasciculus in a healthy adult. Next step will be to apply the methodology in a larger sample of subjects to verify reliability within and across subjects.

Key Investigators:

  • Dartmouth: Andrew Saykin, John West, Robert Roth, Laura Flashman
  • Harvard: Dave Tuch, Josh Snyder, Steve Pieper, Gordon Kindlmann

Links:

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