Difference between revisions of "2010 Summer Project Week Shape"

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<h3>Objective</h3>
 
<h3>Objective</h3>
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Group-wise statistical analysis of brain structures is significant for clinical and neuroanatomy studies. Nevertheless, due to the inherent difficulty to properly represent the morphology of the structures of interest, the statistics is usually limited to volume and surface area measurements. Ideally, we would require an injective shape representation that is invariant rigid or even affine transformations and form a vector space. In the absence of shape representation that meets all of these requirements, it is difficult to define fundamental concepts such as the median or average shape.
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Defining the canonical/median shape having group of shapes.
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We defined a novel measure for shape dissimilarity that is based on shape boundaries. This measure allows us to construct the 'median' of shapes of the same class that provides reacher morphological characteristics of the ensemble. Our goal in this project is to apply the proposed method to a population study of brain structures and test its discriminative power.  
 
 
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<h3>Approach, Plan</h3>
 
<h3>Approach, Plan</h3>
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We use a variational framework based on level-sets to deform a representative (canonical) shape such that the sum of its distances from each of the shapes in the group is minimized.
 
 
We will first test the approach on a set of synthetic shapes where the resulting median shape can be validated. The outcomes of this preliminary stage are expected to guide us in planning more advanced experiments.
 
We will first test the approach on a set of synthetic shapes where the resulting median shape can be validated. The outcomes of this preliminary stage are expected to guide us in planning more advanced experiments.
 
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<h3>Progress</h3>
 
<h3>Progress</h3>
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We are about half way in the process of transforming the Matlab code into ITK having successful preliminary results.
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We made progress in the process of transforming the Matlab code into ITK.
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Specifically we worked on building a new ITK shape metric and incorporating it into our registration framework prior to the construction
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of the 'median' shape.  
  
 
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Latest revision as of 21:58, 13 December 2010

Home < 2010 Summer Project Week Shape

Key Investigators

  • MIT: Tammy Riklin Raviv
  • BWH: Sylvain Bouix

Project

Objective

Defining the canonical/median shape having group of shapes.

Approach, Plan

We will first test the approach on a set of synthetic shapes where the resulting median shape can be validated. The outcomes of this preliminary stage are expected to guide us in planning more advanced experiments.

Progress

We made progress in the process of transforming the Matlab code into ITK. Specifically we worked on building a new ITK shape metric and incorporating it into our registration framework prior to the construction of the 'median' shape.

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