Difference between revisions of "2011 Winter Project Week:Atrial Fibrillation"

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__NOTOC__
 
__NOTOC__
 
<gallery>
 
<gallery>
Image:PW-SLC2011.png|[[2011_Winter_Project_Week#Projects|Projects List]]
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Image:LaSeg1.png | Segmentation of the endocardial surface
Image:genuFAp.jpg|Scatter plot of the original FA data through the genu of the corpus callosum of a normal brain.
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Image:LaSeg2.png | Segmentation of the endocardial surface
Image:genuFA.jpg|Regression of FA data; solid line represents the mean and dotted lines the standard deviation.
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Image:LAsegmentationModuleUI.png | Module UI
 
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==Instructions for Use of this Template==
 
#Please create a new wiki page with an appropriate title for your project using the convention Project/<Project Name>
 
#Copy the entire text of this page into the page created above
 
#Link the created page into the list of projects for the project event
 
#Delete this section from the created page
 
#Send an email to tkapur at bwh.harvard.edu if you are stuck
 
  
 
==Key Investigators==
 
==Key Investigators==
* UNC: Isabelle Corouge, Casey Goodlett, Guido Gerig
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* Georgia Tech: Behnood Gholami, Yi Gao, and Allen Tannenbaum
* Utah: Tom Fletcher, Ross Whitaker
 
  
 
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<h3>Objective</h3>
 
<h3>Objective</h3>
We are developing methods for analyzing diffusion tensor data along fiber tracts. The goal is to be able to make statistical group comparisons with fiber tracts as a common reference frame for comparison.
 
 
 
 
  
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Atrial fibrillation, a cardiac arrhythmia characterized by unsynchronized electrical activity in the atrial chambers of the heart, is a rapidly growing problem in modern societies. Electrical cardioversion and antiarrhythmic drugs are used to manage this condition, but suffer from low success rates and involve major side effects. In an alternative treatment, known as catheter ablation, specific parts of the left atrium are targeted for radio frequency ablation using an intracardiac catheter. Application of radio frequency energy to the cardiac tissue causes thermal injury (lesions), which in turn results into scar tissue. Successful ablation can eliminate, or isolate, the problematic sources of electrical activity and effectively cure atrial fibrillation.
  
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Magnetic resonance imaging (MRI) has been used for both pre- and and post-ablation assessment of the atrial wall. MRI can aid in selecting the right candidate for the ablation procedure and assessing post-ablation scar formations. Image processing techniques can be used for automatic segmentation of the atrial wall, which facilitates an accurate statistical assessment of the region. As a first step towards the general solution to the computer-assisted segmentation of the left atrial wall, in this research we propose a shape-based image segmentation framework to segment the endocardial wall of the left atrium.
  
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We are developing methods to segment the left atrial wall in delayed-enhanced MR imagery.
 
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<h3>Approach, Plan</h3>
 
<h3>Approach, Plan</h3>
  
Our approach for analyzing diffusion tensors is summarized in the IPMI 2007 reference below. The main challenge to this approach is <foo>.
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We plan to  finalize a fully-automatic segmentation approach to identify the blood pool in MRAs. The approach uses the robust statistics segmentation framework developed earlier at Georgia Tech.
 
 
Our plan for the project week is to first try out <bar>,...
 
  
 
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<h3>Progress</h3>
 
<h3>Progress</h3>
Software for the fiber tracking and statistical analysis along the tracts has been implemented. The statistical methods for diffusion tensors are implemented as ITK code as part of the [[NA-MIC/Projects/Diffusion_Image_Analysis/DTI_Software_and_Algorithm_Infrastructure|DTI Software Infrastructure]] project. The methods have been validated on a repeated scan of a healthy individual. This work has been published as a conference paper (MICCAI 2005) and a journal version (MEDIA 2006). Our recent IPMI 2007 paper includes a nonparametric regression method for analyzing data along a fiber tract.
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* We proposed a method combining multi-atlas and active contour to perform the segmentation for the endocardial surface.
  
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* The command line module has been developed and tested on the local built of Slicer3.
  
 
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==Delivery Mechanism==
 
 
This work will be delivered to the NA-MIC Kit as a (please select the appropriate options by noting YES against them below)
 
 
#ITK Module
 
#Slicer Module
 
##Built-in
 
##Extension -- commandline
 
##Extension -- loadable
 
#Other (Please specify)
 
  
 
==References==
 
==References==
*Fletcher P, Tao R, Jeong W, Whitaker R. [http://www.na-mic.org/publications/item/view/634 A volumetric approach to quantifying region-to-region white matter connectivity in diffusion tensor MRI.] Inf Process Med Imaging. 2007;20:346-358. PMID: 17633712.
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* Y. Gao, B. Gholami, R. MacLeod, J. Blauer, W. M. Haddad, and A. R. Tannenbaum, "Segmentation of the Endocardial Wall of the Left Atrium using Localized Region-Based Active Contours and Statistical Shape Learning," Proc. SPIE Med. Imag., San Diego, CA, vol. 7623, 76234Z-1, 2010.
* Corouge I, Fletcher P, Joshi S, Gouttard S, Gerig G. [http://www.na-mic.org/publications/item/view/292 Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis.] Med Image Anal. 2006 Oct;10(5):786-98. PMID: 16926104.
 
* Corouge I, Fletcher P, Joshi S, Gilmore J, Gerig G. [http://www.na-mic.org/publications/item/view/1122 Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis.] Int Conf Med Image Comput Comput Assist Interv. 2005;8(Pt 1):131-9. PMID: 16685838.
 
* Goodlett C, Corouge I, Jomier M, Gerig G, A Quantitative DTI Fiber Tract Analysis Suite, The Insight Journal, vol. ISC/NAMIC/ MICCAI Workshop on Open-Source Software, 2005, Online publication: http://hdl.handle.net/1926/39 .
 
  
 
</div>
 
</div>

Latest revision as of 15:18, 14 January 2011

Home < 2011 Winter Project Week:Atrial Fibrillation

Key Investigators

  • Georgia Tech: Behnood Gholami, Yi Gao, and Allen Tannenbaum

Objective

Atrial fibrillation, a cardiac arrhythmia characterized by unsynchronized electrical activity in the atrial chambers of the heart, is a rapidly growing problem in modern societies. Electrical cardioversion and antiarrhythmic drugs are used to manage this condition, but suffer from low success rates and involve major side effects. In an alternative treatment, known as catheter ablation, specific parts of the left atrium are targeted for radio frequency ablation using an intracardiac catheter. Application of radio frequency energy to the cardiac tissue causes thermal injury (lesions), which in turn results into scar tissue. Successful ablation can eliminate, or isolate, the problematic sources of electrical activity and effectively cure atrial fibrillation.

Magnetic resonance imaging (MRI) has been used for both pre- and and post-ablation assessment of the atrial wall. MRI can aid in selecting the right candidate for the ablation procedure and assessing post-ablation scar formations. Image processing techniques can be used for automatic segmentation of the atrial wall, which facilitates an accurate statistical assessment of the region. As a first step towards the general solution to the computer-assisted segmentation of the left atrial wall, in this research we propose a shape-based image segmentation framework to segment the endocardial wall of the left atrium.

We are developing methods to segment the left atrial wall in delayed-enhanced MR imagery.

Approach, Plan

We plan to finalize a fully-automatic segmentation approach to identify the blood pool in MRAs. The approach uses the robust statistics segmentation framework developed earlier at Georgia Tech.

Progress

  • We proposed a method combining multi-atlas and active contour to perform the segmentation for the endocardial surface.
  • The command line module has been developed and tested on the local built of Slicer3.

References

  • Y. Gao, B. Gholami, R. MacLeod, J. Blauer, W. M. Haddad, and A. R. Tannenbaum, "Segmentation of the Endocardial Wall of the Left Atrium using Localized Region-Based Active Contours and Statistical Shape Learning," Proc. SPIE Med. Imag., San Diego, CA, vol. 7623, 76234Z-1, 2010.