2012 Summer Project Week:DifficultRegistration

• 

  Projects List

• 
• 
• 
• 
• 
• 
• 

BrainsFit NiftyRegIntraOp via BRAINS SIFT Landmark

Key Investigators

• Erasmus Medical Center: Stefan Klein
• University College London: Marc Modat
• UNC: Aditya Gupta, Martin Styner
• BWH: Matthew Toews, Petter Risholm, Dominik Meier, William Wells

Objective

To identify solutions to difficult image registration problems that challenge the limits of current technology. Aspects of difficulty will include:

• inter-subject registration
• truncation, missing tissue
• unknown initialization
• inter-species registration
• articulated deformation

Approach, Plan

A set of difficult pair-wise registration problems will be considered. Participants will discuss workable solutions based on their expertise and background, and these solutions will be documented.
Registration cases can be found here.

• CT: atlas and torso have flipped orientation: Correction Xforms here: Flip CT atlas&torso, zip file with 2 .tfm files

Progress

Three registration approaches evaluated: (NiftyReg), (BrainsFit), (SIFT Landmarks).

• Registration of difficult brain images is successful, body images remain challenging.
• Masking of problematic image regions, e.g. pathology, is an important but time-consuming pre-processing task that could be further investigated or automated. For instance, interactive masking/segmentation of pathology, linking registration and masking.
• Registration direction has an important impact, i.e. which images are designed as fixed or moving. Symmetric or bi-directional registration is helpful.

Delivery Mechanism

Attention Participants: Please log in and update/correct entries in the table below. For bonus points, please provide links or solutions to image registration problems on this page.

Participant	Affiliation	Context	Techniques	Solutions/Links
Steven Aylward	Kitware	CT, US, ressection, brain tumors, changing pathology, sliding organ	Sliding Geometry, Geometric Metamorphosis
Karl Diedrich	AZE	Rigid registration, abdomen	Multi-resolution registration
James Fishbaugh	SCI	Shape analysis and registration
Aditya Gupta	UNC	DTI, enlarged lateral ventricles
Stefan Klein	Erasmus Medical Center	General Registration
Ivan Kolesov	Georia Tech	Articulated, point-based registration
Dominik Meier	BWH	General registration	Slicer: BRAINS	IntraOp: TBI: CT torso: FAILED
Marc Modat	UCL	neuro-deg. diseases, longitudinal	NiftiReg	Some test res
Albert Motillo	GE	Parsing CT, Detection
Simrin Nagpal	Queens University	CT/US registration
Samon Nuranian	UBC	US-guided intervension, spine
Andre Remi	UCLA	Longitudinal changes in TBI, tissue types
Peter Risholm	BWH	Brain, head and neck, radiation therapy	Probabilistic Uncertainty
Samira Sojoudi	UBC	Spine, CT/US registration
Matthew Toews	BWH	General registration	SIFT landmark correspondence	MR-brain: CT-torso:
Bo Wang	Utah	TBI image segmentation
Kevin Wang	Princess Margaret Hospital	Adaptive radiation therapy, longitudinal
William Wells	BWH	Interventional applications	Theory: Segmentation, Registration

Links for Data

• Matt's initial examples
• Slicer Registration Case Library
• XCAT
• DTI Files Enlarged LV registration with normal control
• DWI Files Enlarged LV registration with normal control
• TBI Cases
• TumorSim longitudinal data: To appear at http://midas3.kitware.com

Links for Tools & Methods

• Sliding Geometries Registration: http://public.kitware.com/Wiki/TubeTK
• Geometric Metamorphosis: https://github.com/calaTK/calaTK

Links for Papers

• Sliding Geometries
  • ISBI 2011: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141338/
  • Abdominal Imaging, MICCAI, 2011: http://www.springerlink.com/content/552824638l375645/
• Geometric MetaMorphosis
  • MICCAI 2011: http://www.springerlink.com/content/7r077665012078r5/