Difference between revisions of "NA-MIC Internal Collaborations:DiffusionImageAnalysis"

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=== Tractography Methods ===
 
=== Tractography Methods ===
  
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| style="width:15%" | [[Image:NAMIC callosum tracts prelim.jpg|200px]]
 
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== [[Projects:GeodesicTractographySegmentation|Geodesic Tractography Segmentation]] ==
 
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In this work, we provide an energy minimization framework which allows one to find fiber tracts and volumetric fiber bundles in brain diffusion-weighted MRI (DW-MRI). [[Projects:GeodesicTractographySegmentation|More...]]
 
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<font color="red">'''New: '''</font> J. Melonakos, E. Pichon, S. Angenet, and A. Tannenbaum. Finsler Active Contours. IEEE Transactions on Pattern Analysis and Machine Intelligence, 2007.
 
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| | [[Image:NAMIC callosum tracts prelim.jpg|200px]]
 
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== [[Projects:CorpusCallosumFiberTractography|Corpus Callosum Fiber Tractography]] ==
 
== [[Projects:CorpusCallosumFiberTractography|Corpus Callosum Fiber Tractography]] ==
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The goal of this project is to examine the integrity of fibers in the corpus callosum in patients with schizophrenia and determine whether this is associated with brain activation during memory tasks. [[Projects:CorpusCallosumFiberTractography|More...]]
 
The goal of this project is to examine the integrity of fibers in the corpus callosum in patients with schizophrenia and determine whether this is associated with brain activation during memory tasks. [[Projects:CorpusCallosumFiberTractography|More...]]
  
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<font color="red">'''New: '''</font> Wang P, Saykin A, Flashman L, Wishart H, Rabin L, Santulli R, McHugh T, MacDonald J, Mamourian A. [http://www.na-mic.org/pages/Special:PubDB_View?dspaceid=1133 Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints.] Neurobiol Aging. 2006 Nov;27(11):1613-7.
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<font color="red">'''New: '''</font> Salat D.H., Lee S.Y., van der Kouwe A.J., Greve D.N., Fischl B., Rosas H.D.  
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Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrast. Neuroimage, 2009 Oct 15;48(1):21-8
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| | [[Image:MIT_DTI_JointSegReg_atlas3D.jpg|200px]]
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| | [[Image:GTTubSurfaceSeg-Img1.png|200px]]
 
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== [[Projects:DTIFiberRegistration|Joint Registration and Segmentation of DWI Fiber Tractography]] ==
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== [[Projects:TubularSurfaceSegmentation|Tubular Surface Segmentation Framework]] ==
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The goal of this work is to jointly register and cluster DWI fiber tracts obtained from a group of subjects. [[Projects:DTIFiberRegistration|More...]]
 
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<font color="red">'''New:'''</font>  Ziyan U, Sabuncu M, Grimson W, Westin C. [http://www.na-mic.org/pages/Special:PubDB_View?dspaceid=1137 A Robust Algorithm for Fiber-Bundle Atlas Construction.] In Mathematical Methods in Biomedical Image Analysis (MMBIA 2007): 2007 IEEE Workshop, ICCV 2007 workshop. Rio de Janeiro, Brazil, 2007.
 
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| | [[Image:FiberTracts-angle.jpg|200px]]
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We have proposed a new model for tubular surfaces that transforms the problem of detecting a surface in 3D space, to detecting a curve in 4D space. Besides allowing us to impose a "soft" tubular shape prior, this also leads to computational efficiency over conventional surface segmentation approaches. [[Projects:TubularSurfaceSegmentation|More...]]
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== [[Projects:DTIVolumetricWhiteMatterConnectivity|DTI Volumetric White Matter Connectivity]] ==
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<font color="red">'''New: '''</font> V. Mohan, G. Sundaramoorthi, M. Kubicki and A. Tannenbaum. Tubular Surface Evolution for Segmentation of the Cingulum Bundle From DW-MRI. September 2008.  Proceedings of the Second Workshop on Mathematical Foundations of Computational Anatomy (MFCA'08), Int Conf Med Image Comput Comput Assist Interv. 2008.
  
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We have developed a PDE-based approach to white matter connectivity from DTI that is founded on the principal of minimal paths through the tensor volume. Our method computes a volumetric representation of a white matter tract given two endpoint regions. We have also developed statistical methods for quantifying the full tensor data along these pathways, which should be useful in clinical studies using DT-MRI. [[Projects:DTIVolumetricWhiteMatterConnectivity|More...]]
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<font color="red">'''New: '''</font> V. Mohan, G. Sundaramoorthi and A. Tannenbaum. Tubular Surface Segmentation for Extracting Anatomical Structures from Medical Imagery (in submission). IEEE Transactions on Medical Imaging.
  
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<font color="red">'''New: '''</font> Fletcher P, Tao R, Jeong W, Whitaker R. [http://www.na-mic.org/pages/Special:PubDB_View?dspaceid=634 A volumetric approach to quantifying region-to-region white matter connectivity in diffusion tensor MRI.] Inf Process Med Imaging. 2007;20:346-358.
 
  
 
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| | [[Image:ConnectivityMap.png|200px]]
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| | [[Image:GT-PopStudyVis OnCBs Case19-View2.jpg|200px]]
 
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== [[Projects:DTIStochasticTractography|Stochastic Tractography]] ==
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== [[Projects:TubularSurfaceSegmentationPopStudy|Group Study on DW-MRI using the Tubular Surface Model]] ==
  
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This work calculates posterior distributions of white matter fiber tract parameters given diffusion observations in a DWI volume. [[Projects:DTIStochasticTractography|More...]]
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We have proposed a new framework for performing group studies on DW-MRI data sets using the Tubular Surface Model of Mohan et al. We successfully apply this framework to discriminating schizophrenic cases from normal controls, as well as towards visualizing the regions of the Cingulum Bundle that are affected by Schizophrenia. [[Projects:TubularSurfaceSegmentationPopStudy|More...]]
  
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=== Clustering and Quantitative Analysis ===
 
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| style="width:15%" | [[Image:DTIQuantitativeAnalysis.png|200px]]
 
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== [[Projects:DTIQuantitativeTractAnalysis|Quantitative Analysis of Fiber Tract Bundles]] ==
 
  
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DT-MRI tractography can be used as a coordinate system for computing statistics of diffusion tensor data. The quantitative analysis of diffusion tensors takes into account the space of tensor measurements using a nonlinear Riemannian symmetric space framework.  Tracts of interest are represented as a medial spline attributed with cross-sectional statistics. [[Projects:DTIQuantitativeTractAnalysis|More...]]
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<font color="red">'''New: '''</font> V. Mohan, G. Sundaramoorthi, M. Kubicki and A. Tannenbaum. Population Analysis of the Cingulum Bundle using the Tubular Surface Model for Schizophrenia Detection. SPIE Medical Imaging 2010 (in submission).
  
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<font color="red">'''New: '''</font> Gilmore J, Lin W, Corouge I, Vetsa Y, Smith J, Kang C, Gu H, Hamer R, Lieberman J, Gerig G. [http://www.na-mic.org/pages/Special:PubDB_View?dspaceid=905 Early Postnatal Development of Corpus Callosum and Corticospinal White Matter Assessed with Quantitative Tractography.] AJNR Am J Neuroradiol. 2007 Oct;28(9):1789-95.
 
  
 
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| | [[Image:ZoomedResultWithModel.png|200px]]
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| | [[Image:CingulumAllSubjectsFibers.png|200px]]
 
 
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== [[Projects:DTIClustering|DTI Fiber Clustering and Fiber-Based Analysis]] ==
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== [[Projects:GeodesicTractographySegmentation|Geodesic Tractography Segmentation]] ==
  
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The goal of this project is to provide structural description of the white matter architecture as a partition into coherent fiber bundles and clusters, and to use these bundles for quantitative measurement. [[Projects:DTIClustering|More...]]
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In this work, we provide an energy minimization framework which allows one to find fiber tracts and volumetric fiber bundles in brain diffusion-weighted MRI (DW-MRI). [[Projects:GeodesicTractographySegmentation|More...]]
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<font color="red">'''New:'''</font> Monica E. Lemmond, Lauren J. O'Donnell, Stephen Whalen, Alexandra J. Golby. Characterizing Diffusion Along White Matter Tracts Affected by Primary Brain Tumors. Accepted to HBM 2007.
 
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== [[Projects:DTIModeling|Fiber Tract Modeling, Clustering, and Quantitative Analysis]] ==
 
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The goal of this work is to model the shape of the fiber bundles and use this model discription in clustering and statistical analysis of fiber tracts. [[Projects:DTIModeling|More...]]
 
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<font color="red">'''New:'''</font>
 
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M. Maddah, W. E. L. Grimson, S. K. Warfield, W. M. Wells, A Unified Framework for Clustering and Quantitative Analysis of White Matter Fiber Tracts. Medical Image Analysis, in press.
 
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Maddah M, Wells W, Warfield S, Westin C, Grimson W. [http://www.na-mic.org/pages/Special:PubDB_View?dspaceid=491 Probabilistic clustering and quantitative analysis of white matter fiber tracts.] Inf Process Med Imaging. 2007;20:372-83.
 
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| | [[Image:NAMIC UncinateFasiculus prelim.jpg|200px]]
 
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== [[Projects:FractionalAnisotrophyInTheUncinateFasciculus|Fractional Anisotropy in the Uncinate Fasciculus]] ==
 
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Our objective is to measure the FA in the uncinate fasciculus in patients with schizophrenia. This project is based on the methods published by Kubicki et al. and extends that work by including a bipolar disorder control group, and determining whether there is an association between FA and cognitive functioning and symptoms in the patient groups. [[Projects:FractionalAnisotrophyInTheUncinateFasciculus|More...]]
 
  
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<font color="red">'''New: '''</font> AHM 2007: Training on fiber tractography in Slicer with Sylvain Bouix that we can apply to this project as well as investigation of other fiber tracts such as the cingulate bundle.
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<font color="red">'''New: '''</font> J. Melonakos, E. Pichon, S. Angenet, and A. Tannenbaum. Finsler Active Contours. IEEE Transactions on Pattern Analysis and Machine Intelligence, March 2008, Vol 30, Num 3.
  
 
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=== Other Diffusion Image Algorithms ===
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=== Clustering and Quantitative Analysis ===
  
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| style="width:15%" | [[Image:DartmouthPathOfInterest.png|200px]]
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| style="width:15%" | [[Image:Cbg-dtiatlas-tracts.png|200px]]
 
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== [[Projects:IntegrityOfFrontoTemporalCircuitry|Integrity of Fronto-Temporal Circuitry]] ==
 
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Our objective is to develop methodology that will permit investigators to specify functional MRI regional of interests (fROI) and determine the optimal white matter pathways between the fROIs based on DTI. [[Projects:IntegrityOfFrontoTemporalCircuitry|More...]]
 
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<font color="red">'''New: '''</font> AHM 2007: John West had training session with Dennis Jen on new version of POI algorithm. Worked together to read new Dartmouth 3T Philips Data. Further work ongoing to integrate POI into Slicer 3.
 
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== [[Projects:DTISegmentation|DTI-based Segmentation]] ==
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== [[Projects:DTIPopulationAnalysis|Group Analysis of DTI Fiber Tracts]] ==
  
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Unlike conventional MRI, DTI provides adequate contrast to segment the thalamic nuclei, which are gray matter structures. [[Projects:DTISegmentation|More...]]
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Analysis of populations of diffusion images typically requires time-consuming manual segmentation of structures of interest to obtain correspondance for statistics.  This project uses non-rigid registration of DTI images to produce a common coordinate system for hypothesis testing of diffusion properties. [[Projects:DTIPopulationAnalysis|More...]]
  
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<font color="red">'''New:'''</font> Ziyan U, Tuch D, Westin C. [http://www.na-mic.org/pages/Special:PubDB_View?dspaceid=47 Segmentation of Thalamic Nuclei from DTI Using Spectral Clustering.] Proceedings of the 9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006, LNCS 4191, pp. 807-814, 2006.Segmentation of Thalamic Nuclei from DTI using Spectral Clustering. Accepted to MICCAI 2006.
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<font color="red">'''New: '''</font> Casey B. Goodlett, P. Thomas Fletcher, John H. Gilmore, Guido Gerig. Group Analysis of DTI Fiber Tract Statistics with Application to Neurodevelopment. NeuroImage 45 (1) Supp. 1, 2009. p. S133-S142.
  
 
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== [[Projects:DTINoiseStatistics|Influence of Imaging Noise on DTI Statistics]] ==
 
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Clinical acquisition of diffusion weighted images with high signal to noise ratio remains a challenge.  The goal of this project is to understand the impact of MR noise on quantiative statistics of diffusion properties such as anisotropy measures, trace, etc. [[Projects:DTINoiseStatistics|More...]]
 
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<font color="red">'''New: '''</font> Goodlett C, Fletcher P, Lin W, Gerig G. [http://www.na-mic.org/pages/Special:PubDB_View?dspaceid=1074 Quantification of Measurement Error in DTI: Theoretical Predictions and Validation.] Proceedings of the 10th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2007, LNCS 4791, pp. 10–17, 2007.
 
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== [[Projects:DicomToNrrdForDTI|Notes on the dicom conversion for DTI data]] ==
 
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Report about some observation when converting DTI data from dicom to dwi volumes
 
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[[Projects:DicomToNrrdForDTI|More...]]
 
  
 
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=== Validation ===
 
=== Validation ===
  
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[[Image:Cingulum1.jpg|200px]]
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This project represents a new initiative to build upon a shared vision among Cores 1, 3 and 5 that the field of medical image analysis would be well served by work in the area of validation, calibration and assessment of reliability in DW-MRI image analysis. [[ProjectWeek200706:ContrastingTractographyMeasures|More...]]
 
This project represents a new initiative to build upon a shared vision among Cores 1, 3 and 5 that the field of medical image analysis would be well served by work in the area of validation, calibration and assessment of reliability in DW-MRI image analysis. [[ProjectWeek200706:ContrastingTractographyMeasures|More...]]
  
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<font color="red">'''New: '''</font> [[SanteFe.Tractography.Conference|Contrasting Tractography Methods Conference]], Santa Fe, October 1-2, 2007.
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<font color="red">'''New: '''</font>   S. Pujol, C-F. Westin, R. Whitaker, G. Gerig, T. Fletcher, V. Magnotta, S. Bouix, R. Kikinis, W. M. Wells III, and R. Gollub. Preliminary Results on the use of STAPLE for evaluating DT-MRI tractography in the absence of ground truth. In Proceedings of the 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine ISMRM 2009, April 18-24, 2009. Honolulu, Hawaii. [http://www.ismrm.org/09/ '''ISMRM 2009''']
  
  
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== [[Projects:DTIValidation|DTI Validation]] ==
 
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To carry out quantitative and qualitative validation of the DTI tractography tools. These will be applied to a limited set of specific tracts in single data sets and single tractography tools, and on several data sets using at least two tractography programs and by investigators in different laboratories. [[Projects:DTIValidation|More...]]
 
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</font> Future research is needed to establish critical values for diffusion sequence acquisition parameters that would allow diffusion data processing via Slicer.
 
  
 
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Latest revision as of 18:38, 4 November 2009

Home < NA-MIC Internal Collaborations:DiffusionImageAnalysis
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Diffusion Image Analysis

Tractography Methods

NAMIC callosum tracts prelim.jpg

Corpus Callosum Fiber Tractography

The goal of this project is to examine the integrity of fibers in the corpus callosum in patients with schizophrenia and determine whether this is associated with brain activation during memory tasks. More...

New: Salat D.H., Lee S.Y., van der Kouwe A.J., Greve D.N., Fischl B., Rosas H.D. Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrast. Neuroimage, 2009 Oct 15;48(1):21-8

GTTubSurfaceSeg-Img1.png

Tubular Surface Segmentation Framework

We have proposed a new model for tubular surfaces that transforms the problem of detecting a surface in 3D space, to detecting a curve in 4D space. Besides allowing us to impose a "soft" tubular shape prior, this also leads to computational efficiency over conventional surface segmentation approaches. More...

New: V. Mohan, G. Sundaramoorthi, M. Kubicki and A. Tannenbaum. Tubular Surface Evolution for Segmentation of the Cingulum Bundle From DW-MRI. September 2008. Proceedings of the Second Workshop on Mathematical Foundations of Computational Anatomy (MFCA'08), Int Conf Med Image Comput Comput Assist Interv. 2008.

New: V. Mohan, G. Sundaramoorthi and A. Tannenbaum. Tubular Surface Segmentation for Extracting Anatomical Structures from Medical Imagery (in submission). IEEE Transactions on Medical Imaging.


GT-PopStudyVis OnCBs Case19-View2.jpg

Group Study on DW-MRI using the Tubular Surface Model

We have proposed a new framework for performing group studies on DW-MRI data sets using the Tubular Surface Model of Mohan et al. We successfully apply this framework to discriminating schizophrenic cases from normal controls, as well as towards visualizing the regions of the Cingulum Bundle that are affected by Schizophrenia. More...


New: V. Mohan, G. Sundaramoorthi, M. Kubicki and A. Tannenbaum. Population Analysis of the Cingulum Bundle using the Tubular Surface Model for Schizophrenia Detection. SPIE Medical Imaging 2010 (in submission).


ZoomedResultWithModel.png

Geodesic Tractography Segmentation

In this work, we provide an energy minimization framework which allows one to find fiber tracts and volumetric fiber bundles in brain diffusion-weighted MRI (DW-MRI). More...

New: J. Melonakos, E. Pichon, S. Angenet, and A. Tannenbaum. Finsler Active Contours. IEEE Transactions on Pattern Analysis and Machine Intelligence, March 2008, Vol 30, Num 3.

Clustering and Quantitative Analysis

Cbg-dtiatlas-tracts.png


Group Analysis of DTI Fiber Tracts

Analysis of populations of diffusion images typically requires time-consuming manual segmentation of structures of interest to obtain correspondance for statistics. This project uses non-rigid registration of DTI images to produce a common coordinate system for hypothesis testing of diffusion properties. More...

New: Casey B. Goodlett, P. Thomas Fletcher, John H. Gilmore, Guido Gerig. Group Analysis of DTI Fiber Tract Statistics with Application to Neurodevelopment. NeuroImage 45 (1) Supp. 1, 2009. p. S133-S142.

Validation

Cingulum1.jpg


Contrasting Tractography Measures

This project represents a new initiative to build upon a shared vision among Cores 1, 3 and 5 that the field of medical image analysis would be well served by work in the area of validation, calibration and assessment of reliability in DW-MRI image analysis. More...

New: S. Pujol, C-F. Westin, R. Whitaker, G. Gerig, T. Fletcher, V. Magnotta, S. Bouix, R. Kikinis, W. M. Wells III, and R. Gollub. Preliminary Results on the use of STAPLE for evaluating DT-MRI tractography in the absence of ground truth. In Proceedings of the 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine ISMRM 2009, April 18-24, 2009. Honolulu, Hawaii. ISMRM 2009


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