Difference between revisions of "NA-MIC/Projects/Collaboration/SARP phantom"

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|[[Image:ProjectWeek-2008.png|thumb|320px|Return to [[2008_Summer_Project_Week|Project Week Main Page]] ]]
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|[[Image:genuFAp.jpg|thumb|320px|Scatter plot of the original FA data through the genu of the corpus callosum of a normal brain.]]
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|[[Image:phantomSeg.jpg|thumb|320px|Segmentation of a section of the modified catphan 600 phantom.]]
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===Key Investigators===
 
===Key Investigators===
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* UNC: Isabelle Corouge, Casey Goodlett, Guido Gerig
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* U. of Iowa: Eric Hoffman, Janice Cook Granroth, Keith Gunderson
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* Utah: Tom Fletcher, Ross Whitaker
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* Kitware, Luis Ibanez
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<h1>Objective</h1>
 
<h1>Objective</h1>
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We are developing methods for analyzing diffusion tensor data along fiber tracts. The goal is to be able to make statistical group comparisons with fiber tracts as a common reference frame for comparison.
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The research is funded by SARP -- Severe Asthma Research Program
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<BR>
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Severe asthma affects a small subset of asthma patients but uses a disproportionate amount of health care resources. It is also responsible for a significant amount of the morbidity and mortality associated with asthma. The purpose of this study to establish a collaborative program to investigate the mechanistic basis for severe asthma and how it differs from mild-to-moderate asthma.
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<H2> Technical specifics </H2>
  
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#Compare the results of different scanner brands and kernels quantitatively
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#Investigate homoegeneity (w/ respect to objective 1)
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#Investigage MTF (w/ respect to objective 1)
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#Investigate airway size and wall thickness algorithms (w/ respect to objective 1)
  
 
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<h1>Approach, Plan</h1>
 
<h1>Approach, Plan</h1>
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[http://www.i-clic.org/projects/SARP-UI-PHANTOM.short.ppt Results-to-date]
  
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Our approach for analyzing diffusion tensors is summarized in the IPMI 2007 reference below.  The main challenge to this approach is <foo>.
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Add rotational registration feature.  <br>
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Investigate porting issues <br>
  
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Our plan for the project week is to first try out <bar>,...
 
 
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<h1>Progress</h1>
 
<h1>Progress</h1>
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<H2> Pre-NAMIC status </H2>
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Objective 1,2,3 completed<br>
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Objective 4 is in progress
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<H2> Post-NAMIC updates </H2>
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# Registration details understood, coding underway
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# Two new segmentation approaches to be investigated (Model-based &  Projection/HoughTransform2DCircles)
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# CMake improvents & CTest/ CDash  integration begun (i.e. introduction to CMake-ish tools)
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# Regression & Uniting testing being added
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Software for the fiber tracking and statistical analysis along the tracts has been implemented. The statistical methods for diffusion tensors are implemented as ITK code as part of the [[NA-MIC/Projects/Diffusion_Image_Analysis/DTI_Software_and_Algorithm_Infrastructure|DTI Software Infrastructure]] project. The methods have been validated on a repeated scan of a healthy individual. This work has been published as a conference paper (MICCAI 2005) and a journal version (MEDIA 2006). Our recent IPMI 2007 paper includes a nonparametric regression method for analyzing data along a fiber tract.
 
  
 
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Latest revision as of 13:22, 27 June 2008

Home < NA-MIC < Projects < Collaboration < SARP phantom
Return to Project Week Main Page
Segmentation of a section of the modified catphan 600 phantom.



Key Investigators

  • U. of Iowa: Eric Hoffman, Janice Cook Granroth, Keith Gunderson
  • Kitware, Luis Ibanez

Objective

The research is funded by SARP -- Severe Asthma Research Program
Severe asthma affects a small subset of asthma patients but uses a disproportionate amount of health care resources. It is also responsible for a significant amount of the morbidity and mortality associated with asthma. The purpose of this study to establish a collaborative program to investigate the mechanistic basis for severe asthma and how it differs from mild-to-moderate asthma.

Technical specifics

  1. Compare the results of different scanner brands and kernels quantitatively
  2. Investigate homoegeneity (w/ respect to objective 1)
  3. Investigage MTF (w/ respect to objective 1)
  4. Investigate airway size and wall thickness algorithms (w/ respect to objective 1)

Approach, Plan

Results-to-date

Add rotational registration feature.
Investigate porting issues

Progress

Pre-NAMIC status

Objective 1,2,3 completed
Objective 4 is in progress


Post-NAMIC updates

  1. Registration details understood, coding underway
  2. Two new segmentation approaches to be investigated (Model-based & Projection/HoughTransform2DCircles)
  3. CMake improvents & CTest/ CDash integration begun (i.e. introduction to CMake-ish tools)
  4. Regression & Uniting testing being added





References

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