Core1

Introduction

• History: During MICCAI we (Ron Kikinis, Guido Gerig, Ross Whitaker, Polina Golland, Jim Miller, Tina Kapur, Martin Styner) discussed plans for the current year of NA-MIC. Given that this is the last year for the current participants in Core 3, we need to plan specific activities.
• We will have an information exchange between Core 1 and Core 3 to discuss
  • a) clinical hypothesis and image analysis questions,
  • b) refined existing and new data sets related to a) and
  • c) refined and new algorithms available and ready to meet requirements of a) and b). Emphasis will be on the question what actions to take that will result in NA-MIC clinical application science papers especially w.r.t. the "low hanging fruits" discussed at the AHM.

Logistics

• The venue is the conference room on the second floor of our 1249 Boylston Street Facility (directions) in Boston on October 17 between 9.30am and 3pm.
• Nancy Maxwell will be waiting downstairs to let you in the building. Call her at 617 525 6105 if she is not there.

Agenda

• 09.30am Begin

1. Intro: Ron
2. Core 3: Discussion of newly available data (moderated by Martha Shenton & Andy Saykin)
   1. New Core 3 Data
3. Core 1: Discussion of algorithms and processing capabilities that candidates in this effort (moderated by Ross Whitaker & Guido Gerig).
   1. Diffusion Image Analysis
   2. Shape Analysis
   3. fMRI Analysis

• Identify specific analyses that should be initiated now. Specify teams, interactions and timetables (moderated by Ron Kikinis).
• 03.00pm Adjourn

Core 3.1 Meeting slides, including list of short- and long-term projects

Ongoing Projects

• UF: 2 ROI tractography analysis with mean FA measures, doDTI ... submitted to Brain.
• CF: previously defined ROIs, tractography with behavioral Stroop data, doDTI ... submitted to Archives of General Psychiatry.
• AF: Registration of Susumu Mori’s atlas to our cases. Slicer Nonlinear FA to FA. No results. Need better registration.
• CC: (1) Tractography. Fibers seeded in one slice CC ROI. Automated fiber clustering results in ROI color coded based on fiber clustering (Slicer, MIT Collaboration).

(2) Atlas based approach warping a CC subdivision to individual cases (UNC Collaboration).

• ALIC: Work in progress. Tractography from anterior and posterior limb of the internal capsule. Slicer
• STG: Mean FA, mean diffusivity within ROI defined on SPGR Slicer ... submitted to Biological Psychiatry.

Core 3 Wishes

• Registration:
  • Inter-subject diffusion to diffusion registration.
  • Intra- and inter-subject co-registration of structural, diffusion and functional MRI.
• DWI/tensor/fiber smoothing.
• Fiber asymmetry computation.
• Fiber registration.
• Tractography of white matter structures seeded in gray matter areas.
• 3T artifact removal.
• Segmentation of temporal lobe and basal ganglia.
• Anatomical atlas for white and gray matter.

List of Participants

• Core 1

1. Polina Golland, MIT
2. Guido Gerig, UNC
3. Ross Whitaker, UTAH
4. John Melonakos, Georgia Tech
5. Dennis Jen, MGH
6. Doug Greve, MGH

• Core 3

1. Martha Shenton, PNL
2. Marek Kubicki, PNL
3. Sylvain Bouix, PNL
4. Marc Niethammer, PNL
5. Andy Saykin, Dartmouth
6. John West, Dartmouth

• Other Cores

1. Ron Kikinis, SPL
2. Randy Gollub, MGH and Core 5
3. Steve Pieper, Core 2 and 6
4. Brad Davis, Kitware