NANOMA-collaboration

Overview

The objective of this work is to develop a novel drug delivery system for cancer treatment under Magnetic Resonance Imaging and Navigation. The idea is to exploit the use of magnetic gradient fields in the MR scanner to propel and track the drug coated nano particles simultaneously.

Team

This is a collaborative project involving investigators based in the US and Europe. The expertise of the team includes design and fabrication of nano/micromechanical systems, image processing, navigation algorithms, robotics, modeling and control of smart systems and MR physics. The team comprises of:

• Constantinos Mavroidis (Northeastern University, USA)
• Antoine Ferreira (Ecole Nationale Supérieure d'Ingénieurs, France)
• Christian Dahmen (Carl v. Ossietzky University, Germany)
• Tim Wortmann (Carl v. Ossietzky University, Germany)
• Noby Hata (Brigham and Women's Hospital, Harvard Medical School, USA)
• Jayender Jagadeesan (Brigham and Women's Hospital, Harvard Medical School, USA)
• Panagiotis Vartholomeos (National Technical University of Athens, Greece)

Events

• Teleconference call on January 08, 2009 involving Dinos, Noby, Antoine, Jay and Tim (for Christian) to discuss the short term and long term goals of the project as well as the future course of action.
• Personal meeting on January 31, 2009, in Boston, MA, USA. Participants: Jay, Dinos, Christian and Tim. Discussions about the prospects of joint applications to different open calls. Planning of joint experiments in Boston.
• Experiments with ferromagnetic particles of different sizes in June 2009 in Boston, people involved: Tim, Jay
• Experiments with ferromagnetic particles of different sizes in August 2009 in Boston, people involved: Christian, Jay

Support

This work is being supported by the following grants:

• European Consortium Grant (number: ...)

The following grants have been rejected:

• NSF PIRE (deadline February 26, 2009), Project Acronym MIROMA
• EU: Health call (deadline Oct. 29th, 2009), Project Acronym EMPATHY

The following grants are in negociation:

• EU: FP7-PEOPLE-2009-IRSES (deadline March 27, 2009), Project Acronym MANSFIELD

The following grants have been applied for:

• currently none

It is planned to apply for the following grants:

• currently none

Additionally applications to the following may be useful:

• NIH R01 [[1]]
• possibly different EU HEALTH calls

Progress

• The initial plan of action is being formalized.
• Artefact imaging experiments have been executed
• Analysis of artefacts is undergoing
• Particle actuation has been performed in Oldenburg

Experiments

Planned experiments should analyze the imaging of magnetic particles in the MRI. Different materials and particle sizes will be used.

Possible Materials include:

• Steel (different types)
• ...

Resources

• Siemens Verio 3T MRI scanner (BWH).
• GE Signa 3T MRI scanner at BWH.
• GE Signa 1.5T MRI scanner at BWH.
• Slicer
• "OlVis" - image processing software and algorithms developed at the University of Oldenburg
• MRI software development package at the University of Oldenburg
• Siemens Verio 3T MRI scanner at Pius Hospital in Oldenburg (cooperation with University of Oldenburg)
• Mechanical workshop and manufacturing facilities at University of Oldenburg

Publications

Selected Previous Publications of the Partners

University of Oldenburg

C. Dahmen, T. Wortmann and S. Fatikow: "Magnetic Resonance Imaging of Magnetic Particles for Targeted Drug Delivery", ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010), Houston, Texas, USA, February 7-10, 2010.

R. Bombien, C. Lesche, L. Lozonschi, M. Feucker, R. Brinkmann, C. Dahmen, M. Schünke, J. Cremer, und G. Lutter: "Percutaneous Aortic Valve Replacement: Emerging Tractability for Sufficient Intracardiac Resection of the Aortic Valve", Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, January/February 2010, Volume 5, Issue 1, pp. 55-59. [[2]]

Sergej Fatikow, Christian Dahmen, Tim Wortmann and Robert Tunnell: "Visual Feedback Methods for Nanohandling Automation", International Journal of Information Acquisition, Volume: 6, Issue: 3 (2009) pp. 159-169. [[3]]

T. Wortmann: "Fusion of AFM and SEM Scans", Proc. of Int. Symposium on Optomechatronic Technologies (ISOT), Istanbul, Turkey, September 21-23, 2009. [[4]]

M. Brell, M. Isken, A. Hein, C. Dahmen, R. Tunnell, T. Wortmann, A. Sill, S. Fatikow, R. Bombien, G. Lutter, M. Leester-Schaedel and S. Buettgenbach: “Advanced Multisensor Soft Tissue Navigation for the Controlled Guidance in Intra-Cardiac Microsurgery”, O. Dössel and W.C. Schlegel (Eds.), IFMBE Proceedings, Volume 25/VI11th, International Congress on Medical Physics and Biomedical Engineering (WC2009) , München, Deutschland, September 7 – 12, 2009, ISBN: 978-3-642-03897-6, pp. 345 - 348.

C. Dahmen, T. Wortmann, R. Tunnell, S. Fatikow: "Automatic Extraction of Distance Information from Stereo Images using Tracking Data", Proc. Of the 6th International Conference on Informatics in Control, Automation and Robotics (ICINCO), Milan, Italy, July 2-5, 2009.

C. Dahmen: "Threedimensional Tracking using Object Defocus", Proc. Of the 6th International Conference on Informatics in Control, Automation and Robotics (ICINCO), Milan, Italy, July 2-5, 2009.

T. Wortmann, S. Fatikow: “Carbon Nanotube Detection by Scanning Electron Microscopy”, Proc. of the Eleventh IAPR Conference on Machine Vision Applications (MVA), Yokohama, Japan, May 20-22, 2009. [[5]]

T. Wortmann, C. Dahmen, R. Tunnell, S. Fatikow: “Image Processing Architecture for Real-Time Micro- and Nanohandling Applications”, Proc. of the Eleventh IAPR Conference on Machine Vision Applications (MVA), Yokohama, Japan, May 20-22, 2009. [[6]]

C. Dahmen: "Focus-based depth estimation in the SEM", Proc. of Int. Symposium on Optomechatronic Technologies (ISOT), San Diego, CA, U.S.A., 17-19 November, 2008. [[7]]

S.Fatikow, D.Jasper, C.Edeler, Ch.Dahmen: "Flexible visual feedback for automated nanohandling inside an SEM", Proc. of Int. Symposium on Optomechatronic Technologies (ISOT), San Diego, CA, U.S.A., 17-19 November, 2008. [[8]]

C. Dahmen, T. Wortmann and S. Fatikow: "OlVis: A Modular Image Processing Software Architecture and Applications for Micro- and Nanohandling", Proc. of the Eighth IASTED Int. Conference on Visualization, Imaging and Image Processing (VIIP 2008), Palma de Mallorca, Spain, September 1-3, 2008, pp.245-250 [[9]]

V. Eichhorn, S. Fatikow, Th. Wich, Ch. Dahmen, T. Sievers, K.N. Andersen, K. Carlson and P. Bøggild: "Depth-Detection Methods for Microgripper based CNT Manipulation in a Scanning Electron Microscope", Journal of Micro-Nano Mechatronics, Vol.4, Issue 1, pp.27-36, Springer, 2008. [[10]]

M. Jähnisch, S. Fatikow: "3D Vision Feedback for Nanohandling Monitoring in a Scanning Electron Microscope", International Journal of Optomechatronics, vol. 1, no. 1, pp. 4–26, 2007. [[11]]

Archive

• PDF Documents related to magnetic nanoparticle drug delivery systems:

[[12]]

Experimental Results

• Initial Experimental Data for Quantifying Image Artifacts of Magnetic Capsules done at BWH on 16 June 2009 : File:ImageArtifactsMagneticCapsule1.tar.gz, File:ImageArtifactsMagneticCapsule2.tar.gz
• Image artifact experiments for magnetic particles conducted at BWH on June 20, 2009
• Image artifact experiments for ferro fluids conducted at BWH on June 27, 2009