Latest revision as of 13:23, 18 August 2009

Home < CTSC Imaging Informatics Initiative

Note: This is a work in progress

Overview

The Harvard Catalyst Medical Imaging Informatics Bench to Bedside (mi2b2) Initiative is preparing to provide services for setting up imaging data management systems (IDMS) to support research and clinical efforts involving imaging for Harvard Catalyst affiliated investigators. Two simultaneous (and potentially conflicting) priorities are to 1) provide optimal, customized hardware and software tools for each investigator/ laboratory and 2) to harmonized these solutions to allow for aggregation of the raw and derived medical imaging data for subsequent sharing beyond the investigator/ laboratory.

XNAT has been identified as a potential software solution for providing the core functionalities of a Harvard Catalyst IDMS. A typical IDMS service engagement will include the following steps:

Requirement gathering
Gap analysis
Infrastructure setup
Data modeling
IDMS installation and setup
Data loading
Testing and evaluation
Ongoing data entry, data loading/transfer, and system monitoring and maintenance
System upgrade

mi2b2 Phases

Planning and Information Gathering

The goals of current phase of the initiative are to:

Gather concrete and specific requirements for imaging data transfer and management from a number of high-volume imaging projects led by Harvard Catalyst-affiliated investigators that are generating valuable derived image data with the intention to share that data beyond their own laboratory;
Generate a list of overlapping requirements from these specific investigators;
Prioritize the projects to determine next steps;
Deploy a demo IDMS based on the default XNAT source code;
Assess the effort required to extend XNAT code to support the features identified.

Prototype Development

CHB

Grant Lab

MGH

Dickerson Lab

Production System Development for Selective projects

CHB

MGH

BWH

Use Cases

(Template

Mission
- Description of big picture, goal(s) of project
Participants
Data Types
- Project
- Imaging Modalities
- Genetic
Storage needs
Workflow
- Other software to be integrated (e.g., Osirix)
- other features
Data transfer
Data Management)

The use cases presented here are based on on-going informal interviews with various labs and email communications.

Clinical

Research

Ellen Grant, Rudolph Pienaar, CHB Data Management (Step 1); Query Formulation (Step 2); Tractography Workflow (Step 3)
Stephan Voss, CHB
Simon Warfield, Neil Weisen, CHB Data Management (Step 1); Query Formulation (Step 2); Analysis Workflow (Step 3)
Bill Hanlon, DF/HCC
COPD Gene Project, BWH
Brad Dickerson, Mike Brickhouse, MGH Data Management (Step 1); Query Formulation (Step 2)
Mark Anderson, BWH Data Management (Step 1); Query Formulation (Step 2)

Project Prioritization Criteria

Possible criteria include:

Impact
- Number of users
- Duration of the project
- Amount of data (# of subjects, # of scans ...)

Success Potential
- Commitment of PI
- Feasibility: is it a good fit for using XNAT?
- Availability of project support at each stage of the effort, including requirement gathering, data collection, system testing, continuing IT and informatics support.

Current Status

Test installations of XNAT (1.4 release candidate 2) were done on Windows XP and Linux in VMware. Minor issues in the setup process needs to be fixed to make successful installation on Windows Vista.

Requirement gathering from several research and clinical projects have been conducted.

XNAT 1.4R2 setup/installation process semi-automated.

XNAT extension prototype built.

Explored ways of extracting and loading additional DICOM fields.

7/23/09 Initial user needs assessments have been performed for three use-cases and initial criteria for measuring success of each use case.

7/23/09 Planned approach for setting up XNAT instance at BWH, and identifying an appropriate use-case in the SPL and Image Guided Therapy project.

7/24/09 Requested some example data from Rudolph Pienaar and Brad Dickerson to begin experiments with organizing & uploading onto xnat instances.

Workflow notebook (under development)

look here

Other Software

In addition, an evaluation of dcm4chee|[1] (a DICOM Implementation in JAVA) is in progress. Simon's group runs an instance of dcm4chee. XNAT's DicomServer and DicomBrowser are based on dcm4che.

The Globus MEDICUS (Medical Imaging and Computing for Unified Information Sharing)|[2] has been proposed to provide an image sharing solution.

Reporting and database management of radiological data for clinical trials offered by http://tumormetrics.org/

Evorad Medical Imaging Workstation from http://www.evorad.com/

List of image visualization and analysis software

Neuroimaging

NITRC Funded by the National Institutes of Health Blueprint for Neuroscience Research, NITRC facilitates finding and comparing structural and functional neuroimaging tools and resources. Collecting and pointing to standardized information about tools, this site can help you find the right structural or functional neuroimaging tool or resource and help you decide whether it can help in your research

Commercial

PACS

Fuji Synapse Used at CHB for MR and CT.

Hermes Used at CHB and DFCI for nuclear medicine

GE Centricity system Used at BIDMC, BWH, MGH and DFCI

Amicas web-based application it uses compression techniques to deliver images to the desktop PC for clinical review. It is used primarily by referring clinicians. Used at MGH

AGFA IMPAX Used at MGH.

Workstations

Toshiba Voxar Works on PC. Used at CHB

Merge efilm Works on PC. Used at CHB and MGH

GE Advantage Used at BIDMC, MGH and CHB for postprocessing of CT and MR data.

TeraRecon AquariusNET server connected with PACS to allow clinicians to analyze and segment volumes from routine desktop computers (rather than dedicated workstations). Used at BIDMC and MGH

Siemens Leonardo Used at BIDMC and MGH for Interventional Angiography & Interventional Neuroradiology

MedX, designed especially for medical imaging researchers and system developers. Works on Linux desktop systems. Used at MGH (neurosurgery)

Vital Vitrea for visualization of CT and MR data. Used at CHB, MGH and BIDMC.

Siemens Syngo for 3D image processing. Used at MGH.

Image management

AccelaRAD Virtual Radiology Network (VRN) enables multi-site radiology groups to perform remote reading across geographic boundaries with greater control over report turnaround times and distribution to clients and referring doctors. Used at CHB

Open source

OsirX OsiriX is at the same time a DICOM PACS workstation for imaging and an image processing software for medical research (radiology and nuclear imaging), functional imaging, 3D imaging, confocal microscopy and molecular imaging. For MAC computers. Used at CHB and MGH

myPACS radiology e-teaching files. Used at CHB

k-PACS DICOM Viewing Software for research only. Used at CHB

FSL is a comprehensive library of analysis tools for fMRI, MRI and DTI brain imaging data. Used at CHB, MGH and BWH for research.

MIPAV (Medical Image Processing, Analysis, and Visualization) application enables quantitative analysis and visualization of medical images of numerous modalities such as PET, MRI, CT, or microscopy. Used at BWH

ConQuest Radiology Micro PACS. Used as the Neuro OR desktop micro PACs server at MGH.

SPM has been designed for the analysis of brain imaging data sequences. The sequences can be a series of images from different cohorts, or time-series from the same subject. The current release is designed for the analysis of fMRI, PET, SPECT, EEG and MEG. Works on PC, MAC, Linux. Used at CHB and MGH (training offered at Martinos center)

Research software from Children's Hospital

STAPLE Simultaneous Truth and Performance Level Estimation. Algorithm for assessing a collection of segmentations of an image.

CRkit (Computational Radiology Kit) for automatic and interactive segmentation, registration and visualization.

Research software from Brigham and Women's Hospital

3D Slicer is a multi-platform, free open source software (FOSS) for visualization and image computing.

Research software from Massachusetts General Hospital

Freesursfer is a set of automated and semi-automated tools for the segmentation, reconstruction, and processing of surface-models of the human cerebral cortex. Used for MRI data.

@@ Line 1: / Line 1: @@
-__TOC__
+Back to [[CTSC:CrossSiteImagingIdeas|CTSC_CrossSiteImagingIdeas]]
-== Overview ==
+ '''Note: This is a work in progress'''
-The CTSC Imaging Informatics Initiative (I3) is planning to provide services for setting up imaging data management systems (IDMS) in support of research and clinical efforts involving imaging in Harvard CTSC. XNAT has been identified for providing the core functionalities of the IDMS.
-A typical IDMS service will include the following steps:
+= Overview =
+The Harvard Catalyst Medical Imaging Informatics Bench to Bedside (mi2b2) Initiative is preparing to provide services for setting up imaging data management systems (IDMS) to support research and clinical efforts involving imaging for Harvard Catalyst affiliated investigators.   Two simultaneous (and potentially conflicting) priorities are to 1) provide optimal, customized hardware and software tools for each investigator/ laboratory and 2) to harmonized these solutions to allow for aggregation of the raw and derived medical imaging data for subsequent sharing beyond the investigator/ laboratory.
+<br>
+XNAT has been identified as a potential software solution for providing the core functionalities of a Harvard Catalyst IDMS.
+A typical IDMS service engagement will include the following steps:
 *Requirement gathering
 *Gap analysis
@@ Line 14: / Line 19: @@
 *System upgrade
-The goals of current phase of the initiative are to: 1) gather concrete and specific requirements for imaging data transfer and management from a number of labs in Harvard CTSC; 2)generate overlapping requirements from these specific needs; 3) prioritize the potential projects to determine next steps; 4)Deploy a demo IDMS based on XNAT.
+= mi2b2 Phases =
+== Planning and Information Gathering ==
+The goals of current phase of the initiative are to:
+#Gather concrete and specific requirements for imaging data transfer and management from a number of high-volume imaging projects led by Harvard Catalyst-affiliated investigators that are generating valuable derived image data with the intention to share that data beyond their own laboratory;
+#Generate a list of overlapping requirements from these specific investigators;
+#Prioritize the projects to determine next steps;
+#Deploy a demo IDMS based on the default XNAT source code;
+#Assess the effort required to extend XNAT code to support the features identified.
+== Prototype Development ==
+===CHB===
+*Grant Lab
+===MGH===
+*Dickerson Lab
+== Production System Development for Selective projects==
+===CHB===
+===MGH===
+===BWH===
+= Use Cases =
+(Template
+*Mission
+**Description of big picture, goal(s) of project
+*Participants
+*Data Types
+**Project
+**Imaging Modalities
+**Genetic
+*Storage needs
+*Workflow
+**Other software to be integrated (e.g., Osirix)
+**other features
+*Data transfer
+*Data Management)
 The use cases presented here are based on on-going informal interviews with various labs and email communications.
-== Use Cases ==
-*[[Ellen Grant, CHB]]
-*[[Stephan Voss, CHB]]
-*[[Simon Warfield, CHB]]
-*[[Bill Hanlon, MGH]]
-*[[COPD Gene Project, BWH]]
-*[[Brad Dickerson, MGH]]
-*[[Dan Iosifescu, MGH]]
+==Clinical==
+*[[CTSC_Dan Iosifescu, MGH| Dan Iosifescu, MGH]]
+*[[CTSC_biomarkers_appendicitis| Biomarkers for appendicitis]]
+*[[CTSC_MCI| Mild cognitive impairment]]
+==Research==
+*[[CTSC_Ellen Grant, CHB| Ellen Grant, Rudolph Pienaar, CHB]] Data Management (Step 1);  Query Formulation (Step 2); Tractography Workflow (Step 3)
+*[[CTSC_Stephan Voss, CHB| Stephan Voss, CHB]]
+*[[CTSC_Simon Warfield, CHB| Simon Warfield, Neil Weisen, CHB]] Data Management (Step 1); Query Formulation (Step 2); Analysis Workflow (Step 3)
+*[[CTSC_Bill Hanlon, DF/HCC| Bill Hanlon, DF/HCC]]
+*[[CTSC_COPD Gene Project, BWH| COPD Gene Project, BWH]]
+*[[CTSC_Brad Dickerson, MGH| Brad Dickerson, Mike Brickhouse, MGH]] Data Management (Step 1); Query Formulation (Step 2)
+*[[CTSC_IGT, BWH | Mark Anderson, BWH ]] Data Management (Step 1); Query Formulation (Step 2)
-== Projects Prioritization Criteria==
+= Project Prioritization Criteria=
 Possible criteria include:
 *Impact
@@ Line 40: / Line 91: @@
 **Availability of project support at each stage of the effort, including requirement gathering, data collection, system testing, continuing IT and informatics support.
-== Status ==
+= Current Status =
-Test installations of XNAT (1.4 release candidate 2)  were done on Windows XP. Minor issues in the setup process needs to be fixed to make successful installation on Windows Vista. Effort on setting up XNAT on Linux running in VMware is underway.
+Test installations of XNAT (1.4 release candidate 2)  were done on Windows XP and Linux in VMware. Minor issues in the setup process needs to be fixed to make successful installation on Windows Vista.
+Requirement gathering from several research and clinical projects have been conducted.
+XNAT 1.4R2 setup/installation process semi-automated.
+XNAT extension prototype built.
+Explored ways of extracting and loading additional DICOM fields.
+/23/09 Initial user needs assessments have been performed for three use-cases and initial criteria for measuring success of each use case.
+/23/09 Planned approach for setting up XNAT instance at BWH, and identifying an appropriate use-case in the SPL and Image Guided Therapy project.
+/24/09 Requested some example data from Rudolph Pienaar and Brad Dickerson to begin experiments with organizing & uploading onto xnat instances.
+== Workflow notebook (under development) ==
+look [[CTSC_DataManagementWorkflow | here ]]
+= Other Software =
 In addition, an evaluation of dcm4chee|[http://www.dcm4che.org] (a DICOM Implementation in JAVA) is in progress. Simon's group runs an instance of dcm4chee. XNAT's DicomServer and DicomBrowser are based on dcm4che.
-The Globus MEDICUS (Medical Imaging and Computing for Unified Information Sharing)|[http://dev.globus.org/wiki/Incubator/MEDICUS] has been discussed to provide an image sharing solution.
+The Globus MEDICUS (Medical Imaging and Computing for Unified Information Sharing)|[http://dev.globus.org/wiki/Incubator/MEDICUS] has been proposed to provide an image sharing solution.
+Reporting and database management of radiological data for clinical trials offered by http://tumormetrics.org/
+Evorad Medical Imaging Workstation from http://www.evorad.com/
+= List of image visualization and analysis software=
+==Neuroimaging==
+[http://www.nitrc.org/softwaremap/trove_list.php NITRC] Funded by the National Institutes of Health Blueprint for Neuroscience Research, NITRC facilitates finding and comparing structural and functional neuroimaging tools and resources. Collecting and pointing to standardized information about tools, this site can help you find the right structural or functional neuroimaging tool or resource and help you decide whether it can help in your research
+==Commercial==
+===PACS===
+[http://www.fujimed.com/products-services/network-systems/default.asp?location=1&area=5&id=0&subid=0 Fuji Synapse] Used at CHB for MR and CT.
+[http://www.hermesmedical.com/ Hermes] Used at CHB and DFCI for nuclear medicine
+[http://www.gehealthcare.com/usen/img_info_systems/index.html GE Centricity system] Used at BIDMC, BWH, MGH and DFCI
+[http://www.amicas.com/docs/amicaspacs.pdf Amicas] web-based application it uses compression techniques to deliver images to the desktop PC for clinical review. It is used primarily by referring clinicians. Used at MGH
+[http://www.agfa.com/en/he/solutions/radiology/pacs/index.jsp AGFA IMPAX] Used at MGH.
+=== Workstations===
+[http://www.tmvse.com/Products-and-Services/Voxar-3D-Workstation/ Toshiba Voxar] Works on PC. Used at CHB
+[http://www.merge.com/na/index.html Merge efilm] Works on PC. Used at CHB and MGH
+[http://www.gehealthcare.com/usen/aw/index.html GE Advantage] Used at BIDMC, MGH and CHB for postprocessing of CT and MR data.
+[http://www.terarecon.com/products/aq_net_1_prod.html TeraRecon AquariusNET server] connected with PACS to allow clinicians to analyze and segment volumes from routine desktop computers (rather than dedicated workstations). Used at BIDMC and MGH
+[http://www.medical.siemens.com/webapp/wcs/stores/servlet/CategoryDisplay~q_catalogId~e_-1~a_categoryId~e_1017866~a_catTree~e_100010,1008631,1017866~a_langId~e_-1~a_storeId~e_10001.htm Siemens Leonardo] Used at BIDMC and MGH for Interventional Angiography & Interventional Neuroradiology
+[http://medx.sensor.com/products/medx/overview.html MedX], designed especially for medical imaging researchers and system developers. Works on Linux desktop systems. Used at MGH (neurosurgery)
+[http://www.vitalimages.com/Solutions/Vitrea_Software.aspx Vital Vitrea] for visualization of CT and MR data. Used at CHB, MGH and BIDMC.
+[https://www.medical.siemens.com/webapp/wcs/stores/servlet/PSOptionProductDisplayView?catalogId=-11&catTree=null&langId=-11&productId=145949&productParentId=191771&relatedCatName=Clinical+Applications&storeId=10001 Siemens Syngo] for 3D image processing. Used at MGH.
+===Image management===
+[http://www.accelarad.com/ AccelaRAD Virtual Radiology Network (VRN)] enables multi-site radiology groups to perform remote reading across geographic boundaries with greater control over report turnaround times and distribution to clients and referring doctors. Used at CHB
+==Open source==
+[http://www.osirix-viewer.com/ OsirX] OsiriX is at the same time a DICOM PACS workstation for imaging and an image processing software for medical research (radiology and nuclear imaging), functional imaging, 3D imaging, confocal microscopy and molecular imaging. For MAC computers. Used at CHB and MGH
+[http://www.mypacs.net/repos/mpv3_repo/static/m/Home/ myPACS] radiology e-teaching files. Used at CHB
+[http://www.k-pacs.net/ k-PACS] DICOM Viewing Software for research only. Used at CHB
+[http://www.fmrib.ox.ac.uk/fsl/fsl/list.html FSL] is a comprehensive library of analysis tools for fMRI, MRI and DTI brain imaging data. Used at CHB, MGH and BWH for research.
+[http://mipav.cit.nih.gov/ MIPAV] (Medical Image Processing, Analysis, and Visualization) application enables quantitative analysis and visualization of medical images of numerous modalities such as PET, MRI, CT, or microscopy. Used at BWH
+[http://www.xs4all.nl/%7Eingenium/dicom.html ConQuest Radiology Micro PACS]. Used as the Neuro OR desktop micro PACs server at MGH.
+[http://www.fil.ion.ucl.ac.uk/spm/software/ SPM] has been designed for the analysis of brain imaging data sequences. The sequences can be a series of images from different cohorts, or time-series from the same subject. The current release is designed for the analysis of fMRI, PET, SPECT, EEG and MEG. Works on PC, MAC, Linux. Used at CHB and MGH (training offered at Martinos center)
+==Research software from Children's Hospital==
+[http://www.crl.med.harvard.edu/software/STAPLE/index.php STAPLE] Simultaneous Truth and Performance Level Estimation. Algorithm for assessing a collection of segmentations of an image.
+CRkit (Computational Radiology Kit) for automatic and interactive segmentation, registration and visualization.
+==Research software from Brigham and Women's Hospital==
+[http://www.slicer.org/ 3D Slicer] is a multi-platform, free open source software (FOSS) for visualization and image computing.
+==Research software from Massachusetts General Hospital==
+[http://www.nmr.mgh.harvard.edu/martinos/userInfo/data/sofFreeSurf.php Freesursfer] is a set of automated and semi-automated tools for the segmentation, reconstruction, and processing of surface-models of the human cerebral cortex. Used for MRI data.

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