Events:Computational Methods for Radiation Oncology

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Summary

25 researchers attended this meeting from UNC, BWH, MGH, Harvard, and U Michigan. Several collaboration ideas have emerged and have been enumerated below.

Date and Location

Date: Thursday, May 5, 2011

Location: Surgery Education Office, Room CA-034, Carrie Hall, 15 Francis Street. (Directions)

In addition, the following information is useful for first time visitors to the hospital:

• http://www.brighamandwomens.org/about_bwh/locations/directions/default.aspx
• On the "Pike map" PDF link (bottom of page), the Carrie Hall building is closest to the 15 Francis St entrance -- enter through the columns.
• On Google Street View/Map, the Carrie Hall building is near the label "Howard Hughes Medical Institute".

Agenda

To brainstorm computational methods for radiation oncology between UNC, NA-MIC, BWH.

• 8am: Breakfast
• 8:30-10:30am: UNC -presentations about capabilities of current projects, short term and longer term plans
  • Julian Rosenman PLUNC 18 minutes
  • Gregg Tracton Software for PLUNC, segmentation, registration 10 minutes
  • Stephen Pizer Registration by regression (2 methods), Segmentation via posterior optimization, training probability distributions on s reps and quantile functions, segmentation via correspondence-preserving warps, ant aliasing 23 minutes
  • Sha Chang Nanotube imaging, incl. for IGRT 10 minutes
  • Brandon Frederick Iterative tomographic reconstruction, CTs at treatment time, gpu’s 15 minutes
  • Derek Merck 3D visualization via model-guided rendering, 3D visualization in PLUNC for RTP 15 minutes
  • Ilknur Kabul Texturing of surfaces, onion skins, and cut planes; interpolation of textures 10 minutes
  • Hina Shah Registration of endoscopic cine and CT of throat,fused displays of these two registered sources 8 minutes
  • Ron Alterovitz Planning for brachytherapy with curved needles, FEM software 12 minutes
• 10:30 am: Break
• 11:50am-2:30pm NA-MIC/Harvard presentations about capabilities of current projects, short term and longer term plans
  • AMIGO (Tina Kapur) (5 minutes)
  • Slicer3 to Slicer 4, Radiation Therapy support today, and plans for the next year (slides) (Steve Pieper) (30 minutes)
  • SPARKit, Canadian grant for providing open source software platform for radiotherapy, potentially based on NA-MIC Kit (slides) (Andras Lasso) (10minutes)
  • Head and Neck Cancer NA-MIC DBP (slides) (Greg Sharp) (15 minutes)
  • Gynecologic Cancer Brachytherapy Plans (Tina Kapur) (10 minutes)
  • Shadie, shading language for volume visualization (slides) (Hanspeter Pfister, Milos Hasan, George Chen, John Wolfgang) (20 minutes)
• Continue presentations...
• 2:30pm: Intro of afternoon objectives (Julian Rosenman)
• 2:45pm: What UNC/Boston system combinations ought to be developed -- the Boston perspective (Tina Kapur)
• 3pm: What Boston/UNC system combinations ought to be developed -- the UNC perspective (Steve Pizer)
• 3:30pm: Comments from Kitware about their capabilities relevant to proposed combinations (Brad Davis)
• 4-5pm
  • Break and subgroup formation (e.g., merging surgical and radiation treatment planning system; 3D visualization software for treatment planning; image analysis software for treatment planning)
  • Subgroups sketch out mechanics for collaborations (http://grants.nih.gov/grants/guide/pa-files/PAR-11-028.html?)
  • Summary: what we do next?

Participants

1. Julian Rosenman, Radiation Oncology, UNC
2. Gregg Tracton, Radiation Physics UNC
3. Stephen Pizer, CS and Rad Onc UNC
4. Sha Chang, Radiation Physics UNC
5. Brandon Frederick, UNC
6. Derek Merck, UNC
7. Ilknur Kabul UNC
8. Hina Shah UNC
9. Ron Alterovitz UNC
10. Ron Kikinis BWH
11. Clare Tempany BWH
12. Ferenc Jolesz BWH
13. Sandy Wells BWH
14. Steve Pieper Isomics
15. Andras Lasso Queens
16. Greg Sharp MGH
17. Tina Kapur BWH
18. Hanspeter Pfister Harvard
19. George Chen MGH
20. Petter Risholm BWH
21. Andrey Fedorov BWH
22. James Balter U Michigan
23. Brad Davis Kitware
24. Andinet Enquobahrie Kitware
25. Firdaus Janoos BWH

Potential Areas of Collaboration

1. Multimodal registrations from BWH with PLUNC
2. ITK needs GPU codes
3. How to put UNC code into the open source world (from BWH experience)
4. Visual bookmarks as cf. Slicer (scene views)
5. Tolerance and other surface color washes on textured objects
6. Endoscopy and 3D MR segmentation: cervix
7. AMIGO w/ endoscopy
8. AMIGO w/ curved needles
9. Curved needles for biopsies
10. Optical CT inclusion
11. FEM modeling sharings between BWH and UNC
12. Robotics and device tracking sharing: BWH has device tracking expertise: OPENIGT
13. Shadie/MGRView or 3D PLUNC or 3D Slicer integration
14. Adding cmake/software process to PLUNC
15. Problem: how to integrate object-based coordinate systems into object models and integrate UI controls within those coordinate systems?
16. MGRView w/ ray-cast volume rendering a la volview/vtk
17. Inclusion of Ontario ARKit/SparKit? (adaptive RT)
18. What can be taken from PLUNC into Slicer right away?
19. There needs to be a remodeling of PLUNC licensing to meet the Slicer sharing philosophy
20. US-to-MR or -CT registration brought to RT
21. Visualize uncertainty by painting over texture (Pfister/UNC)
22. Combine Shadie language with MGRView/PLUNC 3Dview capabilities
23. Image analysis and visualization via Slicer (selected modules in use) into PLUNC into MOSAIQ, etc.
24. PLUNC Need: Flexibility/refactor?. Multimodal registration. Including context; annotations
25. Is there a role for python, numpy?
26. Note: WashU CERR has a simple dose engine. Do we integrate that?
27. 2d-3d Registration for IGRT using Nanotube Stationary Tomosynthesis from Siemens, Xinray
28. Head and Neck Segmentation by registration and refinement
29. Antialiasing algorithm
    1. How will antialiasing impact DVHs? What is the drift in the dose distribution
    2. Morphomics Segmentation software for Prostate and Cervix maybe
30. James balter collaboration LA problem
31. ITK should have GPU support
32. Potential tools from UNC:
    1. Antialiasing software (potential project week project -- steve pizer, brad davis, petter risholm, andriy fedorov)
    2. Iterative reconstruction software is shareable
    3. General GPU tools
    4. Manual Editing of alignment
    5. Dose accumulation calculation
33. Mechanisms
    1. Software maintenance R01
    2. BRP collaborative grant
34. Registration of endoscopic images with CT for IGRT: Gyn colposcopy
35. Steerable needle planning for gyne brachytherapy
36. How to close the loop with feedback for needle insertion and steering for prostate brachy?
37. Open FEM standard for RT
38. Slicer License for UNC review: http://www.slicer.org/pages/LicenseText
39. http://wiki.na-mic.org/Wiki/index.php/2011_Summer_Project_Week