CTSC Imaging Informatics Initiative

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Overview

The Harvard Catalyst Medical Imaging Informatics Bench to Bedside (mi2b2) Initiative is planning to provide services for setting up imaging data management systems (IDMS) in support of research and clinical efforts involving imaging in Harvard CTSC. XNAT has been identified for providing the core functionalities of the IDMS. A typical IDMS service will include the following steps:

• Requirement gathering
• Gap analysis
• Infrastructure setup
• Data modeling
• IDMS installation and setup
• Data loading
• Testing and evaluation
• Ongoing data entry, data loading/transfer, and system monitoring and maintenance
• System upgrade

mi2b2 Phases

Planning and Information Gathering

The goals of current phase of the initiative are to:

1. Gather concrete and specific requirements for imaging data transfer and management from a number of labs in Harvard CTSC;
2. Generate overlapping requirements from these specific needs;
3. Prioritize the potential projects to determine next steps;
4. Deploy a demo IDMS based on XNAT.

Prototype Development

CHB

• Grant Lab

MGH

• Dickerson Lab

Use Cases

(Template

• Mission
  • Description of big picture, goal(s) of project
• Participants
• Data
  • Project
  • Imaging Modalities
  • Genetic
• Workflow
  • Other software to be integrated (e.g., Osirix)
  • other features
• Data transfer
• Data Management)

The use cases presented here are based on on-going informal interviews with various labs and email communications.

Clinical

• Dan Iosifescu, MGH
• Biomarkers for appendicitis
• Mild cognitive impairment

Research

• Ellen Grant, CHB
• Stephan Voss, CHB
• Simon Warfield, CHB
• Bill Hanlon, DF/HCC
• COPD Gene Project, BWH
• Brad Dickerson

Project Prioritization Criteria

Possible criteria include:

• Impact
  • Number of users
  • Duration of the project
  • Amount of data (# of subjects, # of scans ...)

• Success Potential
  • Commitment of PI
  • Feasibility: is it a good fit for using XNAT?
  • Availability of project support at each stage of the effort, including requirement gathering, data collection, system testing, continuing IT and informatics support.

Current Status

Test installations of XNAT (1.4 release candidate 2) were done on Windows XP and Linux in VMware. Minor issues in the setup process needs to be fixed to make successful installation on Windows Vista.

Requirement gathering from several research and clinical projects have been conducted.

Other Software

In addition, an evaluation of dcm4chee|[1] (a DICOM Implementation in JAVA) is in progress. Simon's group runs an instance of dcm4chee. XNAT's DicomServer and DicomBrowser are based on dcm4che.

The Globus MEDICUS (Medical Imaging and Computing for Unified Information Sharing)|[2] has been proposed to provide an image sharing solution.

Reporting and database management of radiological data for clinical trials offered by http://tumormetrics.org/

Evorad Medical Imaging Workstation from http://www.evorad.com/