Difference between revisions of "Projects:FieldmapFreeDistortionCorrection"
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= Key Investigators = | = Key Investigators = | ||
− | *Clare Poynton, | + | * MIT: Clare Poynton, Polina Golland |
+ | * BWH/Harvard:Alex Golby, William (Sandy) Wells | ||
+ | * Oxford: Mark Jenkinson | ||
= Publications = | = Publications = |
Revision as of 21:54, 14 May 2009
Home < Projects:FieldmapFreeDistortionCorrectionContents
Introduction
Echo-planar imaging (EPI) is one of the most widely used pulse sequences in functional magnetic resonance imaging (fMRI) due to its high temporal resolution. The ability to acquire an entire volume within seconds makes it a valuable, non-invasive tool for probing dynamic physiological processes such as the blood-oxygenation-level-dependent (BOLD) response. A significant limitation of EPI is its sensitivity to magnetic field inhomogeneity. Perturbations in the field result in signal loss and geometric distortion in EPI data. Previous studies have shown that correcting geometric distortion in functional images increases the accuracy of co-registration to structural MR. Precise anatomical localization of functional activation is especially important in single-subject studies (ie. pre-surgical evaluation) and in cases where the structural MR is used as a reference to sample the functional data (ie. cortical-surface-based analysis). Therefore, field inhomogeneity and distortion is a significant problem in fMRI. In this work, we describe a method for correcting the distortions present in echo planar images (EPI) and registering the EPI to structural MRI. A fieldmap is predicted from a tissue/air segmentation of the MRI using a perturbation method and subsequently used to unwarp the EPI data. Shim and other missing parameters are estimated by registration. We obtain results that are similar to those obtained using fieldmaps, however neither fieldmaps, nor knowledge of shim parameters is required.
Registration without Correction
Localization of functional information relies on accurate registration of EPI and structural MR, which can be difficult due to EPI distortion caused by B0 field inhomogeneity. Correcting distortion using acquired Fieldmaps has been shown to improve registration [1], but Fieldmaps may not be available or may not be applicable if significant motion is present in the EPI, resulting in sub-optimal registration.
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Problem 1: Segmentation
Magnetic field models exist to compute a Fieldmap from a Tissue/Air segmentation [2,3], but segmenting structural MR is difficult due to the similar intensities of bone and air. In the Fieldmap-Free method [4], T1 MRI was segmented using a trained classifier that computes the probability of tissue given MR intensity. CT data was used for training and validation only, allowing the trained classifier to be applied to data sets without CT.
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Problem 2: Shim Estimation
Existing magnetic field models do not account for the shim fields that reduce B0 field inhomogeniety prior to acquisition. Without this information, accurate unwarping is not possible. In this Method, a Fieldmap (without shim) was computed from the Segmented MR using the field model in [2]. Missing Shim Fields were modeled by spherical harmonic basis functions. Registration was used to search over shim parameters until optimal agreement between the EPI and structural MR was obtained.
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[1] Cusack et al, NeuroImage 18:127-142. 2003.
[2] Jenkinson et al, Magn Reson Med 52:471-477. 2004.
[3] Koch et al, Phys Med Biol. 51(24):6381-402. 2006.
[4] Poynton et al, MICCAI. 271-279, 2008.
Key Investigators
- MIT: Clare Poynton, Polina Golland
- BWH/Harvard:Alex Golby, William (Sandy) Wells
- Oxford: Mark Jenkinson
Publications
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