NA-MIC Internal Collaborations:DiffusionImageAnalysis

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Diffusion Image Analysis

Tractography Methods

Corpus Callosum Fiber Tractography The goal of this project is to examine the integrity of fibers in the corpus callosum in patients with schizophrenia and determine whether this is associated with brain activation during memory tasks. More... New: Salat D.H., Lee S.Y., van der Kouwe A.J., Greve D.N., Fischl B., Rosas H.D. Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrast. Neuroimage, 2009 Oct 15;48(1):21-8

Clustering and Quantitative Analysis

Group Analysis of DTI Fiber Tracts Analysis of populations of diffusion images typically requires time-consuming manual segmentation of structures of interest to obtain correspondance for statistics. This project uses non-rigid registration of DTI images to produce a common coordinate system for hypothesis testing of diffusion properties. More... New: Casey B. Goodlett, P. Thomas Fletcher, John H. Gilmore, Guido Gerig. Group Analysis of DTI Fiber Tract Statistics with Application to Neurodevelopment. NeuroImage 45 (1) Supp. 1, 2009. p. S133-S142.

Fiber Tract Modeling, Clustering, and Quantitative Analysis The goal of this work is to model the shape of the fiber bundles and use this model discription in clustering and statistical analysis of fiber tracts. More... New: Maddah M., Zollei L., Grimson W.E.L., Westin C., Wells III W.M. , A Mathematical Framework for Incorporating Anatomical Knowledge in DT-MRI Analysis . Proceedings of the 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro 2008; 4543943: 105–108.

Validation

Contrasting Tractography Measures This project represents a new initiative to build upon a shared vision among Cores 1, 3 and 5 that the field of medical image analysis would be well served by work in the area of validation, calibration and assessment of reliability in DW-MRI image analysis. More... New: S. Pujol, C-F. Westin, R. Whitaker, G. Gerig, T. Fletcher, V. Magnotta, S. Bouix, R. Kikinis, W. M. Wells III, and R. Gollub. Preliminary Results on the use of STAPLE for evaluating DT-MRI tractography in the absence of ground truth. In Proceedings of the 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine ISMRM 2009, April 18-24, 2009. Honolulu, Hawaii. ISMRM 2009