NANOMA-collaboration

Overview

The objective of this work is to develop a novel drug delivery system for cancer treatment under Magnetic Resonance Imaging and Navigation. The idea is to exploit the use of magnetic gradient fields in the MR scanner to propel and track the drug coated nano particles simultaneously.

Team

This is a collaborative project involving investigators based in the US and Europe. The expertise of the team includes design and fabrication of nano/micromechanical systems, image processing, navigation algorithms, robotics, modeling and control of smart systems and MR physics. The team comprises of:

• Constantinos Mavroidis (Northeastern University, USA)
• Antoine Ferreira (Ecole Nationale Supérieure d'Ingénieurs, France)
• Christian Dahmen (Carl v. Ossietzky University, Germany)
• Tim Wortmann (Carl v. Ossietzky University, Germany)
• Noby Hata (Brigham and Women's Hospital, Harvard Medical School, USA)
• Jayender Jagadeesan (Brigham and Women's Hospital, Harvard Medical School, USA)
• Panagiotis Vartholomeos (National Technical University of Athens, Greece)

Events

• Teleconference call on January 08, 2009 involving Dinos, Noby, Antoine, Jay and Tim (for Christian) to discuss the short term and long term goals of the project as well as the future course of action.
• Personal meeting on January 31, 2009, in Boston, MA, USA. Participants: Jay, Dinos, Christian and Tim. Discussions about the prospects of joint applications to different open calls. Planning of joint experiments in Boston.
• Experiments with ferromagnetic particles of different sizes in June 2009 in Boston, people involved: Tim, Jay
• Experiments with ferromagnetic particles of different sizes in August 2009 in Boston, people involved: Christian, Jay

Support

This work is being supported by the following grants:

• European Consortium Grant (number: ...)
• ...
• ...

The following grants have been rejected:

• NSF PIRE (deadline February 26, 2009), Project Acronym MIROMA
• EU: Health call (deadline Oct. 29th, 2009), Project Acronym EMPATHY

The following grants are in negociation:

• EU: FP7-PEOPLE-2009-IRSES (deadline March 27, 2009), Project Acronym MANSFIELD

The following grants have been applied for:

• none at the moment

It is planned to apply for the following grants:

• currently none

Additionally applications to the following may be useful:

• NIH R01 [[1]]
• possibly different EU HEALTH calls

Progress

• The initial plan of action is being formalized.
• Artefact imaging experiments have been executed
• Analysis of artefacts is undergoing

Experiments

Planned experiments should analyze the imaging of magnetic particles in the MRI. Different materials and particle sizes will be used.

Possible Materials include:

• Steel (different types)
• ...

Resources

• Siemens Verio 3T MRI scanner (BWH).
• GE Signa 3T MRI scanner at BWH.
• GE Signa 1.5T MRI scanner at BWH.
• Slicer
• Image processing software and algorithms developed at the University of Oldenburg
• MRI software development package at the University of Oldenburg
• Siemens Verio 3T MRI scanner at Pius Hospital in Oldenburg (cooperation with University of Oldenburg)

Publications

Selected Previous Publications of the Partners

University of Oldenburg

M. Jähnisch, S. Fatikow: "3D Vision Feedback for Nanohandling Monitoring in a Scanning Electron Microscope", International Journal of Optomechatronics, vol. 1, no. 1, pp. 4–26, 2007. [[2]]

V. Eichhorn, S. Fatikow, Th. Wich, Ch. Dahmen, T. Sievers, K.N. Andersen, K. Carlson and P. Bøggild: "Depth-Detection Methods for Microgripper based CNT Manipulation in a Scanning Electron Microscope", Journal of Micro-Nano Mechatronics, Vol.4, Issue 1, pp.27-36, Springer, 2008. [[3]]

Archive

• PDF Documents related to magnetic nanoparticle drug delivery systems:

[[4]]

Experimental Results

• Initial Experimental Data for Quantifying Image Artifacts of Magnetic Capsules done at BWH on 16 June 2009 : File:ImageArtifactsMagneticCapsule1.tar.gz, File:ImageArtifactsMagneticCapsule2.tar.gz
• Image artifact experiments for magnetic particles conducted at BWH on June 20, 2009
• Image artifact experiments for ferro fluids conducted at BWH on June 27, 2009