DBP2:QueensFinal:2010

back to DBP2 Main

!!! The page is under construction !!!

test2

Overview

A 3D Slicer based end-to-end application was developed for MRI-guided prostate biopsy (implemented as a Slicer 3.6 module, ProstateNav). The application supports multiple targeting devices (a transrectal and transperineal robotic device and a transperineal template), multiple needle types (for biopsy and seed placement). Automatic and semi-automatic registration of the targeting device to the planning image coordinate system is implemented using 4 line fiducials or a 3 orthogonal Z-shaped fiducials. During the planning phase the clinicians can define several point targets. 3D Slicer platform provides felexible visualization of several diagnostic image types (T2, contrast-enhanced, etc.). In the targeting phase the software computes targeting parameters for each target that allows the targeting devices to position the needles accurately. The software offers means for quantitatively assess the needle placement accuracy. Patient motion during the intervention (dislocation and deformation between the planning and verification images) can be easily visualized, reducing the chance of incorrect needle placement during lengthy procedures. The software is tested at three clinical sites, at Brigham and Women's Hospital, NIH National Cancer Institute, and Johs Hopkins Hospital in several phantom experiments and also evaluated on patients.

In addition to this software application, preliminary prostate segmentation and registration algorithms were also developed. The initial results are encouraging and are published in journals and presented at conferences. Current algorithm implementations are stored in the NA-MIC sandbox repository and after optimization and tuning they planned to be added to the clinical application.

Papers

• Xu, H., A. Lasso, S. Vikal, P. Guion, A. Krieger, A. Kaushal, L. L. Whitcomb, and G. Fichtinger, "MRI-Guided Robotic Prostate Biopsy: A Clinical Accuracy Validation", Medical Image Computing and Computer-Assisted Intervention (MICCAI 2010), In Press.
• Tadayyon, H., A. Lasso, S. Gill, A. Kaushal, P. Guion, and G. Fichtinger, "Target Motion Compensation in MRI-guided Prostate Biopsy with Static Images", EMBC2010 - 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Buenos Aires, Argentina, pp. 5416-5419, 2010.
• Lasso, A., S. Avni, and G. Fichtinger, "Targeting Error Simulator for Image-guided Prostate Needle Placement", EMBC2010 - 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Buenos Aires, Argentina, pp. 5424-5427, 2010.
• Xu, H., A. Lasso, S. Vikal, P. Guion, A. Krieger, A. Kaushal, L. Whitcomb, and G. Fichtinger, "MRI-Guided Transrectal Robotic Prostate Biopsy Validation", The American Association of Physicists in Medicine (AAPM) Annual Meeting 2010, July 18-22, vol. 37, 3128 (2010), Philadelphia, Pennsylvania, pp. 3128-3129, 2010.
• Xu, H., A. Lasso, S. Vikal, P. Guion, A. Krieger, A. Kaushal, L. Whitcomb, and G. Fichtinger, "Clinical Accuracy of Robot-Assisted Prostate Biopsy in Closed MRI Scanner", The Hamlyn Symposium on Medical Robotics, The Royal Society, London, UK, 25 May 2010, 2010.
• Xu, H., A. Lasso, S. Vikal, P. Guion, A. Krieger, A. Kaushal, L. L. Whitcomb, and G. Fichtinger, "Accuracy validation for MRI-guided robotic prostate biopsy", Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling, San Diego, California, USA, SPIE, pp. 762517 - 762517-8, 2010.
• Tadayyon, H., G. Fichtinger, A. Lasso, S. Vikal, and S. Gill, "MRI-Guided prostate motion tracking by means of multislice-to-volume registration", SPIE Medical Imaging, 02/2010.
• Lasso, A., J. Tokuda, S. Vikal, C. M. Tempany, N. Hata, and G. Fichtinger, A generic computer assisted intervention plug-in module for 3D Slicer with multiple device support. Medical Image Computing and Computer-Assisted Intervention (MICCAI), London, UK, 2009
• Vikal, S., S. Haker, C. Tempany, and G. Fichtinger, Prostate contouring in MRI guided biopsy", SPIE Medical Imaging, vol. 7259, 2009.
• Boisvert, J., D. Gobbi, S. Vikal, R. Rohling, G. Fichtinger, and P. Abolmaesumi An open-source solution for interactive acquisition, processing and transfer of interventional ultrasound images. Workshop on Systems and Architectures for Computer Assisted Interventions, held in conjunction with the 11th International Conference on Medical Image Computing and Computer Assisted Intervention , 2008.
• Fischer G.S., Krieger A., Iordachita I., Csoma C., Whitcomb L., Fichtinger G. MRI Compatibility of Robot Actuation Techniques - A Comparative Study. Int Conf Med Image Comput Comput Assist Interv. 2008;11(Pt 2):509-517.
• Gill S., Abolmaesumi P., Vikal S., Mousavi P., Fichtinger G. Intraoperative Prostate Tracking with Slice-to-Volume Registration in MRI. Proceedings of the 20th International Conference of the Society for Medical Innovation and Technology 2008; 154-158.
• Krieger, A., P. Guion, C. Csoma, I. Iordachita, A. Singh, A. Kaushal, C. Menard, G. Fichtinger, and L. Whitcomb. Design and Preliminary Clinical Studies of an MRI-Guided Transrectal Prostate Intervention System. International Society of Magnetic Resonance in Medicine (ISMRM), 2008.
• Mewes P., Tokuda J., DiMaio S.P., Fischer G., Csoma C., Gobbi D., Tempany C.M., Fichtinger G., Hata N. Integrated System for Robot-Assisted in Prostate Biopsy in Closed MRI Scanner. Proceedings of the IEEE International Conference on Robotics and Automation 2008; 2959-2962.
• Tokuda, J., S. DiMaio, G. Fischer, C. Csoma, D. Gobbi, G. Fichtinger, N. Hata, and C. Tempany, "Real-time MR Imaging Controlled by Transperineal Needle Placement Device for MRI-guided Prostate Biopsy", 16th Scientific Meeting and Exhibition of International Society of Magnetic Resonance in Medicine, 2008.
• Tokuda J., Fischer G.S., Csoma C., DiMaio S.P., Gobbi D.G., Fichtinger G., Tempany C.M., Hata N. Software Strategy for Robotic Transperineal Prostate Therapy in Closed-Bore MRI. Int Conf Med Image Comput Comput Assist Interv. 2008;11(Pt 2):701-709.
• Vikal, S., S. Haker, C. Tempany, and G. Fichtinger, "Prostate contouring in MRI guided biopsy", Workshop on Prostate image analysis and computer-assisted intervention, International Conference on Medical Image Computing and Computer Assisted Intervention , 2008.
• Gao, Y., R. Sandhu, G. Fichtinger, A. Tannenbaum, "A coupled global registration and segmentation framework with application to magnetic resonance prostate imagery", IEEE Trans Med Imaging (accepted, 05/ 27/2010)
• Gao, Y., A. Tannenbaum, "Shape based MRI prostate image segmentation using local information driven directional distance Bayesian method", Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling, San Diego, California, USA, SPIE, pp. 762308-1 - 762308-9, 2010.

Software

ProstateNav: MRI-guided prostate biopsy module with multiple device support

• Implements a complete MRI-guided biopsy workflow: calibration, planning, targeting, verification
• Supports multiple devices: trans-rectal robot, trans-perineal template, trans-perineal robot
• Provides 3D visualization of patient images, targets, devices in the control and scanner room
• Latest stable version is available in Slicer 3.6.1 release. Latest development version source code is available in the NA-MIC Sandbox.
• Tutorial: presentation, data set

Listing and short description of the sample data

• Clinical data sets of MRI-guided prostate biopsies
  • 63 anonymized prostate MRI sequences of 5 patients (Pt*), acquired at NIH-NCI, PI-s: Camphausen, Kausal and Pinto.
  • Imaging sessions: (date).Diag = diagnostic; (date).B(id), (date).LR(id), (date).HR(id) = trans-rectal prostate biopsy
  • Image types: Needle Ax = needle insertion confirmation image; SAG 3POINT PLAN = calibration image
• Tutorial data set
  • One clinical data set of robot-assisted trans-rectal prostate biopsy, contains calibration, planning, and verification images

Links

namic wiki slicer documentation pages of the NIH collaborators

-add your best picture(s) -tie the references to the text and where possible to pubdb -write a short section about plans forward looking (OCAIRO, grant applications etc.) -create a section with links to other webpages (namic wiki, slicer documentation, pages of the NIH collaborators)

[1]