Non-rigid MR-CT Image Registration

Non-rigid MR-CT Image Registration Tutorial

Overview

This tutorial demonstrates how to perform a pre-operated contrast enhanced MR image to intra-procedure CT image non-rigid registration. The case study is CT-guided liver tumor cryoablation.

NON-RIGID MR-CT IMAGE REGISTRATION: This tutorial demonstrates how to perform MR-CT and CT-CT non-rigid registrations. In a CT-guided cryoablation of a liver tumor, we can see the tumor on the preoperative MRI but not on the intra-operative CT image (only cryoprobes visible). The non-rigid registration is used for image fusion to better visualize tumor margins and location, as shown in this figure.

Clinical significants

• Non-rigid registrations desirable to compensate for liver deformation caused by patient positioning, respiratory motion, and interventional manipulation.
• A multi-modality non-rigid registration method can enhance visualization of tumor margins and location during the planning, targeting, and monitoring phases of CT imaging-guided cryoablation procedure.

IMAGE PROCESSING IN CRYOABLATION OF LIVER CASE: In CT-guided cryoablation, there are a non-rigid registration, (2) an affine registration and (3) a resampling as shown in this figure. These three tasks will be performed in this tutorial.

Tutorial Topics / Targets

• Slicer Modules Used:
  • N41ITKBiasField Correction
  • Editor
  • BRAINSFitIGT Registration
• Image Processing Tasks Performed:
  • Intensity non-uniformly correction
  • Mask generation / segmentation
  • Inter-modality non-rigid image registration
• Image Data Used:
  • Pre-operative abdominal MR with surface coil, showing liver
  • Planning and Intra-operative CT with cryo-probe

Overview

• This tutorial will go through the following steps (in order):
• Preprocessing
  • MRI mask generation
  • CT mask generation
  • MRI Bias Field Intensity Correction
• Registration
  • MRI-CT non-rigid registration
  • CT-CT affine registration
  • Resampling & Fusion

Tutorials

Non-rigid MR-CT Image Registration Tutorial ‏ [ppt]‏ [pdf]

Tutorial materials

Material data:

• Non-rigid_MR_CT_Image_RegistrationTutorialData_TutorialContestSummer2011.tar.gz

People

Atsushi Yamada, Ph.D. (Research Associate, Brigham and Women's Hospital and Harvard Medical School)
Dominik S. Meier, Ph.D. (Assistant Professor, Brigham and Women's Hospital and Harvard Medical School)
Nobuhiko Hata, Ph.D. (Associate Professor, Brigham and Women's Hospital and Harvard Medical School)