Projects:MGH-HeadAndNeck-PtSetReg

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Semi-Automatic Image Registration

We recognize that the difference between a failure of an automatic image registration approach and a success of a semi-automatic method can be a small amount of user input. The goal of this work is to register two CT volumes of different patients that are related by a large deformation. The user sets two thresholds for each image: one for the bone mask and another for flesh tissue. This operation is not time consuming but simplifies the registration task dramatically for the automatic algorithm.

Description

In this example, large misalignment is present between the two patients.

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Original Misalignment of the volumes.

Point clouds are generated from label maps of bone. The computed registration field, which is guaranteed to be injective, is applied to the original CT volumes.

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Point clouds representing bone tissue of the patients (before and after registration).

Another set of point clouds is generated by sampling from label maps of flesh created for the images from the previous step. To avoid undoing the previous registration, regions belonging to the registered bone tissue from above are constrained not to move. Again, an injective deformation field is computed.

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Point clouds representing flesh tissue of the patients (before and after registration). This step is constrained.

The results of applying the two deformation computed by the proposed process are shown below.

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Aligned images using the two step registration process.

Current State of Work

A pipeline composed of Matlab and mex-ed C++ code has been implemented.

Key Investigators

• Georgia Tech: Ivan Kolesov, Patricio Vela
• Boston University: Jehoon Lee, Allen Tannenbaum
• MGH: Gregory Sharp

Publications

In Press

I. Kolesov, J. Lee, P.Vela, G. Sharp and A. Tannenbaum. Diffeomorphic Point Set Registration with Landmark Constraints. In Preparation for PAMI.