Difference between revisions of "2014 Project Week:TBIatrophy"
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<h3>Objective</h3> | <h3>Objective</h3> | ||
| − | * | + | * To quantitatively assess and map gray matter (GM) atrophy in a group of TBI subjects across the first 6 months post-injury. |
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<h3>Approach, Plan</h3> | <h3>Approach, Plan</h3> | ||
| − | * | + | * the study will be implemented in accordance with the Declaration of Helsinki and with approval from the UCLA and USC Institutional Review Boards |
| + | * multimodal neuroimaging data acquired from patients admitted to the Neurointensive Care Unit of the UCLA Ronald Reagan Medical Center will be used | ||
| + | * a Siemens Magnetom Trio Tim scanner with a magnetic field strength of 3 T was used to acquire T1- and T2-weighted magnetic resonance imaging (MRI) volumes both acutely and chronically (at several days as well as ~6 months post-injury, respectively) | ||
| + | * after affine co-registration of all acquired MRI volumes within each subject, segmentation and cortical thickness calculations will be performed using freely-available methodologies available in 3D Slicer | ||
| + | * user supervision and manual correction will be implemented by three experienced users with training in neuroanatomy. | ||
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Revision as of 19:52, 10 December 2013
Home < 2014 Project Week:TBIatrophy
Key Investigators
Andrei Irimia, PhD (Institute for Neuroimaging and Informatics, University of Southern California)
SY Matthew Goh, BS (Institute for Neuroimaging and Informatics, University of Southern California)
Carinna M. Torgerson, BS (Institute for Neuroimaging and Informatics, University of Southern California)
John D. Van Horn, PhD (Institute for Neuroimaging and Informatics, University of Southern California)
Project Description
Objective
- To quantitatively assess and map gray matter (GM) atrophy in a group of TBI subjects across the first 6 months post-injury.
Approach, Plan
- the study will be implemented in accordance with the Declaration of Helsinki and with approval from the UCLA and USC Institutional Review Boards
- multimodal neuroimaging data acquired from patients admitted to the Neurointensive Care Unit of the UCLA Ronald Reagan Medical Center will be used
- a Siemens Magnetom Trio Tim scanner with a magnetic field strength of 3 T was used to acquire T1- and T2-weighted magnetic resonance imaging (MRI) volumes both acutely and chronically (at several days as well as ~6 months post-injury, respectively)
- after affine co-registration of all acquired MRI volumes within each subject, segmentation and cortical thickness calculations will be performed using freely-available methodologies available in 3D Slicer
- user supervision and manual correction will be implemented by three experienced users with training in neuroanatomy.
