Project Week 25/SALT Spatiotemporal Modeling:

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Key Investigators

• James Fishbaugh (NYU Tandon School of Engineering, USA)
• Guido Gerig (NYU Tandon School of Engineering, USA)

Project Description

Objective	Approach and Plan	Progress and Next Steps
Slicer Shape AnaLysis Toolbox (SlicerSALT) is a standalone version of Slicer specifically for shape analysis, currently under development. One aspect of the project is the validation of the tools to be included in SlicerSALT. In this project, we will begin validating the shape regression component with a longitudinal database of subcortical structures.	Longitudinal dataset consists of 553 subjects with a total of 1530 scans. MR images are acquired at clustered ages of 1, 2, 4, 6, 8, and 10 years of age. Subjects commonly have missing data points, though many subjects have 3 or more more scans. We focus this week on getting the data organized, setting up the processing pipeline, as well as estimating a model for a single subject. We would also like to identify Slicer tools that are helpful for our analysis, to be considered for inclusion in Slicer SALT.

Illustrations

Left) Acquisitions of a single subject with observations at 1, 2, 4, 6, and 8 years old. Right) Sub-cortical structures are segmented for each time point.

Continuous spatiotemporal model of all subcortical structures from 0 to 8 years of age. Color denotes speed in mm/year, with vectors showing direction of growth. Two views of the same growth trajectory is shown below, from the side and from the front.

Background and References

• SlicerSALT