Difference between revisions of "Projects:NeuralSubstratesOfApathy"

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= Neural Substrates Of Apathy =
 
 
 
  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
 
  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
  
'''Objectives'''
+
= Neural Substrates Of Apathy =
  
 
We recently observed reduced volume of the frontal lobe in patients with schizophrenia having high levels of apathy (link to journal below). In the present investigation we are extending our study of the structural correlates of apathy in schizophrenia using the NAMIC toolkit with an emphasis on basal ganglia.
 
We recently observed reduced volume of the frontal lobe in patients with schizophrenia having high levels of apathy (link to journal below). In the present investigation we are extending our study of the structural correlates of apathy in schizophrenia using the NAMIC toolkit with an emphasis on basal ganglia.
  
'''Progress'''
+
= Description =
  
 
Data acquired at 1.5T on 20 patients with schizophrenia and 20 healthy controls at Dartmouth. Have begun to apply 3D Slicer for manual segmentation. Additional subject accrual ongoing.
 
Data acquired at 1.5T on 20 patients with schizophrenia and 20 healthy controls at Dartmouth. Have begun to apply 3D Slicer for manual segmentation. Additional subject accrual ongoing.
  
'''Key Investigators'''
+
= Key Investigators =
  
 
* Dartmouth: Robert Roth, Laura Flashman, Andrew Saykin, Thomas McAllister
 
* Dartmouth: Robert Roth, Laura Flashman, Andrew Saykin, Thomas McAllister
 
* Isomics: Steve Pieper
 
* Isomics: Steve Pieper
  
'''Links'''
+
= Links =
  
 
* Paper, American Journal of Psychiatry 2004, Volume 161, Issue 1: [http://ajp.psychiatryonline.org/cgi/content/abstract/161/1/154 Apathy in Schizophrenia: Reduced Frontal Lobe Volume and Neuropsychological Deficits]
 
* Paper, American Journal of Psychiatry 2004, Volume 161, Issue 1: [http://ajp.psychiatryonline.org/cgi/content/abstract/161/1/154 Apathy in Schizophrenia: Reduced Frontal Lobe Volume and Neuropsychological Deficits]
 
* [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]
 
* [[DBP:Sylvain_Doug_visit_Dartmouth_Feb_22_2006|Feb 22, 2006: Sylvain Bouix to visit Dartmouth]]
 
* [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]
 
* [[DBP:Dartmouth_Harvard_Slicer_Training_12_01_2005|December 1, 2005 Dartmouth Group Slicer Training Followup at Harvard, 1249 Boylston]]

Revision as of 01:31, 28 November 2007

Home < Projects:NeuralSubstratesOfApathy
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Neural Substrates Of Apathy

We recently observed reduced volume of the frontal lobe in patients with schizophrenia having high levels of apathy (link to journal below). In the present investigation we are extending our study of the structural correlates of apathy in schizophrenia using the NAMIC toolkit with an emphasis on basal ganglia.

Description

Data acquired at 1.5T on 20 patients with schizophrenia and 20 healthy controls at Dartmouth. Have begun to apply 3D Slicer for manual segmentation. Additional subject accrual ongoing.

Key Investigators

  • Dartmouth: Robert Roth, Laura Flashman, Andrew Saykin, Thomas McAllister
  • Isomics: Steve Pieper

Links