NA-MIC/Projects/Collaboration/SBIA UPenn

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Key Investigators

• Ragini Verma, SBIA, UPenn <Ragini.Verma@uphs.upenn.edu>
• Christos Davatzikos
• Yang Li <Yang.Li@uphs.upenn.edu>
• Luke Bloy <lbloy@seas.upenn.edu>

Objective

To incorporate into Slicer, processing and analysis methods for DTI and HARDI being developed at the Section of Biomedical Image Analysis (SBIA), UPenn [1]. The main components will be plugins for DTI registration and manifold-based statistics followed by methods for HARDI registration and statistics.

Approach, Plan

• DTI registration: has been developed in SBIA over a period of 2 years, mainly using in-house code (not in ITK). This will be incorporated as a plugin.
• DTI Statistics: SPM-like package for statistics on the full tensor. The proposed format is again a plugin as it is based on code already existing in SBIA in C, C++.
• HARDI registration: This is being developed in ITK, building on HARDI representation format currently under development
• HARDI statistics: being developed in ITK

Progress

• DTI Registration: plugin is ready and will be demonstrated

To do: Replace the affine registration component, help file, speed, version control

• Need help with:

1. General representation for registration in ITK

2. Code for Demons DTI registration for comparison

3. Visualization: tensor glyphs and ODFs