Projects:DiffusionMeasuresAlongFiberTracts

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Objective: To quantify changes in diffusion properties along the cingulum bundle for schizophrenics and normal controls.

Progress: We improved the diffusion MRI module in slicer to allow for a better fiber selection (based on multiple regions of interest) as well as fiber clustering. We set up a processing pipeline to allow for statistical computations of fiber diffusion properties across the fibers of a fiber bundle and along the bundle itself. Further, we are in the process of developing a continuous representation of fiber bundles (see Figure) to allow for a more geometric computation of bundle diffusion quantities.

Key Investigators:

• Harvard PNL: Marc Niethammer, Sylvain Bouix, Marek Kubicki, Mark Dreusicke, Martha Shenton
• MIT: CF Westin, Lauren O'Donnell, Raul San Jose

Links:

• DBP:Harvard:Collaboration:MITDTI
• http://pnl.bwh.harvard.edu/index.html

Cingulum bundle with arclength parameterization.