2017 Winter Project Week/LORDWI

Key Investigators

• Henrik Groenholt Jensen, UCPH
• Lauren J. O'Donnell, BWH
• Tina Kapur, BWH
• Fan Zhang, BWH
• Carl-Fredrik Westin, BWH

Project Description

Objective	Approach and Plan	Progress and Next Steps
Evaluate/validate the density-based registration framework for DWI developed at UCPH (this is a nonrigid model - see the link below for a paper on the global algorithm).	Figure out what diffusion data is available (preferably data already evaluated by another registration model). Discuss best ways to validate results (tractography, biomarkers, synthetic data, phantoms, others?). So far we have visually tested inter-subject registrations of HCP data and intra-subject multi-shell, and intra-subject on young brain tumor subjects. Consider if Slicer can be used in tandem for evaluation. This method introduces Mutual Information to nonrigid registration of DWI. Discuss if other similarity measures (e.g. correlation measures) would be better suited for specific problems.

Background and References

• MICCAI paper on early framework: http://link.springer.com/chapter/10.1007/978-3-319-24571-3_37