FMA (Protege) links to Slicer

Exploration of Foundational Model of Anatomy's representation of brain

Scatter plot of the original FA data through the genu of the corpus callosum of a normal brain.

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Key Investigators

• UNC: Isabelle Corouge, Casey Goodlett, Guido Gerig
• Utah: Tom Fletcher, Ross Whitaker

Objective

We are developing methods for analyzing diffusion tensor data along fiber tracts. The goal is to be able to make statistical group comparisons with fiber tracts as a common reference frame for comparison.

Approach, Plan

Our approach for analyzing diffusion tensors is summarized in the IPMI 2007 reference below. The main challenge to this approach is <foo>.

Our plan for the project week is to first try out <bar>,...

Progress

Software for the fiber tracking and statistical analysis along the tracts has been implemented. The statistical methods for diffusion tensors are implemented as ITK code as part of the DTI Software Infrastructure project. The methods have been validated on a repeated scan of a healthy individual. This work has been published as a conference paper (MICCAI 2005) and a journal version (MEDIA 2006). Our recent IPMI 2007 paper includes a nonparametric regression method for analyzing data along a fiber tract.

References

• Florin's paper on the functional ontology
• C. Rosse and J.L.V. Mejino, A reference ontology for biomedical informatics: the Foundational Model of Anatomy. J. Biomed Inform. 36:478-500, 2003.