2008 Summer Project Week:RegionalCorticalThicknessTool

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Key Investigators

• UNC: Heather Cody Hazlett, Martin Styner, Clement Vachet
• GE: Jim Miller

Objective

We would like to create an end-to-end application within Slicer3 allowing individual and group analysis of regional and local cortical thickness.

Such a workflow applied to the young brain (2-4 years old) is our goal in order to start a longitudinal study of early brain development in autism (UNC DBP).

See our Roadmap for more details.

Approach, Plan

Our plan for the project week is to start the development of a work flow tool allowing regional cortical thickness analysis. Pipeline:

- Tissue segmentation: itkEMSCLP UNC external Slicer3 module
- Skull Stripping: in progress (UNC Slicer3 external modules) - ImageMath and SegPostProcess Slicer3 modules
- Lobar parcellation registration
  - Atlas to case affine registration: AffineRegistration module
  - Atlas to case BSPline registration: Deformable BSpline registration module
  - Applying transformation to parcellation map: Resample Volume 2 module
- Cortical Thickness: CortthickCLP (UNC Slicer3 external module)

Progress

Attended:

- Special topic breakout: Non-rigid registration
- Special topic breakout: GWE