2009 Summer Project Week Lupus Lesion Segmentation

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  Projects List

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  Manual tracing of lupus lesions.

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  Predicted Heat Map.

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  Heat Map after thresholding.

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  Lesion model inside brain.

Key Investigators

• MRN: H. Jeremy Bockholt, Mark Scully
• Isomics: Steve Pieper

Objective

To create an end-to-end Lupus lesion segmentation and analysis pipeline that can work in both an automated and semi-supervised fashion.

See our Roadmap for more details.

Approach, Plan

Our approach involves the combination of morphometric features with a non-linear classifier in order to capture more of the gestalt properties a human rater uses when segmenting Lupus lesions.

Our plan for the project week is to:

• Work with Steve Pieper to implement the wizard interface to the lesion analysis module to make the segmentation process easier.
• Refactor the lesion analysis code and integrate it with the Slicer code repository so it is built with Slicer.
• Meet with the white matter lesion segmentation group to discuss overlap.

Progress

• Charted the logic of the wizard interface and Steve Pieper produced a prototype.
• Made the lesion segmentation module available as a downloadable extension. This obviates the need to add the source code to the Slicer repository.
• Met with the white matter lesion segmentation project group from UNC / GE to exchange data and discuss methods.
• Updated tutorial reflecting feedback from dissemination core.
• Improved testing coverage of lesion segmentation tools.