2011 Summer Project Week White Matter Laterality

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  Projects List

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  before automatic midsagittal alignment

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  after automatic midsagittal alignment. Note increased symmetry (green laterality indices, near 0)

White Matter Laterality/Asymmetry Measurement

Key Investigators

• Harvard Medical School: Lauren O'Donnell
• Kitware: JC (Thanks for help on how to integrate as a Slicer4 module/extension)
• Harvard Medical School: Sandy Wells (Thanks for helpful discussions on angle representation and objective functions for registration)

Objective

1. Fast computation of white matter

   fiber tract laterality indices

   in python and ... Slicer4

Approach, Plan

1. So far have preliminary code running in python/vtk

   Slicer-ification is goal for this week

   Another goal: learn how to make an extension module

   Another goal: can this module use testing framework

Progress

1. Project is now organized as a python package

   Command line script written to run on large groups

   Initial testing on R/L handedness group data showed significant differences

   Preprocessing and midsagittal alignment have been implemented

References

The fiber laterality histogram: A new way to measure white matter asymmetry. Lauren J. O'Donnell, Carl-Fredrik Westin, Isaiah Norton, Stephen Whalen, Laura Rigolo, Ruth Propper, and Alexandra J. Golby Med Image Comput Comput Assist Interv. 2010; 13(Pt 2): 225-232

Delivery Mechanism

This work will be delivered to the NAMIC Kit as a

1. NITRIC distribution
2. Slicer Module
   1. Built-in:
   2. Extension -- commandline:
   3. Extension -- loadable: