2014 Project Week:LongitudinalDTI
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Home < 2014 Project Week:LongitudinalDTI
Key Investigators
- Utah: Anuja Sharma, Bo Wang, Guido Gerig
- UCLA: Andrei Irimia, John D. Van Horn
- UNC: Martin Styner
Project Description
Objective
- Patient specific modeling of longitudinal changes in white matter integrity along tracts, with emphasis on seemingly unaffected regions of the brain.
- Identify changes in fiber tract architecture along with possible loss of fibers along time.
- Correlate changes in tract geometry with the evolution of diffusion properties.
- Specific goals for this week include DTI pre-processing to improve the quality of the tractography results that we have obtained in the past for our dataset.
Approach, Plan
- Quality check of the TBI data using DTIPrep to correct for DTI related imaging artifacts, including checking for potential bias fields.
- Validation of the estimated DTI via glyph visualizations.
- Longitudinal co-registration of the patient's scans followed by tractography to verify the consistency of the extracted white matter tracts.
- Comparison of diffusion profiles along tract in a longitudinal setup to identify possible changes at the chronic timepoint.
