Projects:ImagingPhenotypesInSchizophrenicsAndControls

Back to Irvine DBP 1, Toronto DBP 1

Imaging Phenotypes in Schizophrenics and Controls

In a legacy dataset of 28 chronic schizophrenics, to determine fMRI activation during working memory in schizophrenia and apply novel tools to assess circuitry between regions through combining behavior and BOLD signal analyses.

Description

The data have been analyzed individually and through various group analyses using Partial Least Squares analysis. The initial results are being presented at the Human Brain Mapping meeting in Florence IT 2006.

Jim Fallon has given 7 invited talks recently on this project:

• 2008 Ohio State University June 9-13, 2008 NSF Mathematical Biosciences Institute
• 2007 National Academy of Sciences- Invited talk to Division of Behavioral and Social Sciences -November : The application of Imaging Genetics to functional, clinical, and basic multidisciplinary studies,”
• 2007 Technion, Israel ICMAN Symposium Keynote Talk “The application of Imaging Genetics to Gene Discovery and Understanding Disease Subtypes”
• 2007 XIII ESCAP (European Society of Child and Adolescent Psychiatry) International Congress Invited “Main” Lecture “
• 2007 Arizona State University Law School and the Sandra Day O’Connor US Courthouse Symposium on NeuroLaw: Invited Plenary Lecture on Brain Imaging and the Law.
• 2006 ISCTM Satellite on the NIMH Initiative Regarding Treatment Development for Negative Symptoms Washington DC “The Neurobiology of Negative Symptom Schizophrenia”
• 2006 Imaging Genetics Studies of Cognitive and Affective Disorders University of Oslo

Key Investigators

• Irvine DBP 1: Adrian Preda, Jessica Turner, James Fallon
• Toronto DBP 1: Fabio Macciardi, James Kennedy, Aristotle Voineskos

Links

The data can be found via the NAMIC website: http://www.na-mic.org/Wiki/index.php/DataRepository#UCI_Structural.2C_Functional_and_PET_Images.2C_Genetic_and_Clinical_Data