DBP3:Utah:RegCases

Back to Utah AFib DBP

Background

• The CARMA Center uses late gadolinium enhanced MRI (LGE-MRI) images to evaluate new patients, predict procedural success, and evaluate therapeutic outcomes. The MRI images for each patient are further accompanied by MR angiographic images (MRA) and manual segmentations of relevant structures. These images are acquired longitudinally over the course of a patient's evaluation, treatment, and follow-up (i.e. months or years). Registration is often necessary to compare images from different time points in a patient's treatment, across patient cohorts at the same stage of disease progression or treatment, or different image types.

LGE-MRI Image	Segmentation of LGE-MRI Image	MRA Image

Registration Case Types

Pre-ablation LGE to Post-ablation LGE

• Frequently, clinicians ask about the ability to directly compare the pre-ablation and post-ablation LGE scans.
• Accurate registration of longitudinal LGE scans allows for assessment of disease progression, structural remodeling of the cardiac tissue, and ablation-induced lesion formation.

Pre-ablation LGE/Endo to Post-ablation LGE/Endo

• Combined the LGE images and manual segmentations can be used to improve the quality of registration.
• Yi Gao previously developed a Slicer module to register pre- and post-ablation images driven by the LGE images/segmentations -> AFib Registration

Implementation

• We will develop a Slicer extension module with pre-defined registration parameters for each of the above scenarios.