DBP 2010

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Motivations and Procedure

The original RFA specified the following:

• In core 3, an investigator will propose 2-4 collaborations with NIH funded biomedical or behavioral researchers to address a biomedical/behavioral question using computational approaches. It is not essential that the biomedical researchers have expertise in computational biology, but they should have a question that will drive the fundamental computational research in cores 1 and 2. The purpose of this core is to ensure that the research carried out in cores 1 and 2 has direct relevance to biomedical or behavioral research. It may be useful for these Driving Biological Projects (DPB's) to have a focus on a particular disease or organ, but that sort of focus might not be appropriate for all NIH NCBCs. It is expected that many of the biomedical researchers in core 3 will not be at the same institution as the parent NIH NCBC. In such cases, convincing plans for collaboration at a distance must be presented in the proposal.

NIH has approved the following procedure for NA-MIC (tcon with Grace Peng (program officer) and Karen Skinner (lead science officer) on 11/10/2005):

• 1. Solicitation of nominations from core 1 and 2 members. Candidates have to have existing NIH funding (or equivalent) and joint publications with at least one Core 1 or Core 2 member.

• 2. Core 1 and 2 PI's, and the PI will select 3-4 candidates and invite them to submit a four-page proposal, including a plan how they will adopt the NA-MIC kit. The PI will consult with the NIH team.

• 3. Core 1 and Core 2 PI's and the PI solicit input from the NA-MIC team, based on the document and additional discussions with the candidates. We will then choose the "winner/s" and invite them to submit a RO1 style proposal to the NA-MIC leadership.

First Round of Selection process: Solicitation

Prerequisites

• Candidates have to have existing NIH funding as PI or co-investigator
• Joint publications with at least one Core 1 or Core 2 member.
• Willingness to adopt the NA-MIC kit
• Willingness to use DBP funds to hire at least one computer science person into the DBP to help translational efforts

Spring 2009: First stage proposal, deadline March 1

We intend to minimize the effort for both the candidates and the decision makers. For your convenience, you can refer potential DBP candidates to our short NA-MIC overview. We are looking for a short text that addresses the following points:

• Abstract from the qualifying NIH grant (or comparable short description of the driving project), grant # and program officer
• What is the history with the core 1 or core 2 "sponsor" (1 paragraph)
• What is the benefit to the DBP applicant (1 paragraph)
• What is the benefit to NA-MIC (1 paragraph)