2009 Winter Project Week WFU2

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Key Investigators

• Virginia Tech: Chris Wyatt
• Virgina Tech: Vidya Rajagopalan
• TBD

Objective

We have developed a deformation based morphometry approach that combines multiple registration methods, using the log-Euclidean framework, to help remove bias in DBM based studies. The goal of this project is to interface this code with slicer using CLP modules.

Approach, Plan

The existing code is an ITK-based command line program that operates on vector fields and produces Jacobians averaged over the registation algorithm. We have another command line program that does permutation testing of hypothesized group differences.

Progress

TODO:

• develop CLP module for existing ITK-based code
• develop means to do permutation testing within slicer (list of files in groups?)

References

• Peters DC, Wylie JV, Hauser TH, Kissinger KV, Botnar RM, Essebag V, Josephson ME, Manning WJ. Detection of pulmonary vein and left atrial scar after catheter ablation with three-dimensional navigator-gated delayed enhancement MR imaging: initial experience. Radiology 2007; 243:690-695.
• Taclas JE, Wylie JV, Hauser TH, Manning WJ, Josephson ME, Peters, DC. Correlation and Visualization of Left Atrial Scar due to Pulmonary Vein Ablation with Recorded Ablation Sites. Proceedings of the 16th scientific meeting of the International Society for Magnetic Resonance in Medicine (2008), Toronto, CA, p. 1042.
• Malchano ZJ, Neuzil P, Cury RC, Holmvang G, Weichet J, Schmidt EJ, Ruskin JN, Reddy VY. Integration of cardiac CT/MR imaging with three-dimensional electroanatomical mapping to guide catheter manipulation in the left atrium: implications for catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 2006; 17:1221-1229.