Two-tensor tractography in Slicer using Python and Teem
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Key Investigators
- BWH: Madeleine Seeland
- BWH: Carl-Fredrik Westin
- BWH: Gordon Kindlmann
- BWH: Nobuhiko Hata
Objective
Our objective is to finalize the integration of the Two-Tensor Streamline Tractography method in [1] into Slicer and to test it on diverse DWI datasets. Furthermore the optimal parameter settings to run the algorithm needs to be investigated.
Approach, Plan
We are integrating the Two-Tensor Streamline Tractography into Slicer. The complete details on the method are summarized in [1].
The implementation of our project is carried out in Python. The Two-Tensor Tractography function calls are already implemented in the Teem library and can be accessed using the Python wrappings for Teem.
Besides the integration of the Two-Tensor Tractography algorithm into Slicer, the optimal parameter settings for the algorithm needs to be investigated.
Furthermore we need to find a way to parallelize the tractography algorithm (one idea is to use IPython).
Another plan is to apply a noise filter on the DWI's before applying the Two-Tensor Tractography algorithm, as this may lead to more accurate fiber results.
Progress
- The implementation of the Two-Tensor Tractography is already finished. Currently I'm testing the algorithm with different parameter settings.
- Extension of the Two-Tensor Tractography module by fiudical seeding.
- Working on using Grid Wizard Enterprise tool ([1]) to parallelize the execution of my algorithm (thanks to Marco Guiz and Luca Antiga for helping me making this possible)
References
- [1] Qazi AA, Radmanesh A, O'Donnell L, Kindlmann G, Peled S, Whalen S, Westin CF, Golby AJ. Resolving crossings in the corticospinal tract by two-tensor streamline tractography: method and clinical assessment using fMRI. Neuroimage 2008
- [2] Peled S, Friman O, Jolesz F, Westin CF. Geometrically constrained two-tensor model for crossing tracts in DWI. Magnetic Resonance Imaging 2006;24:1263-1270.
