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Objective: Use fiber clustering in multiple subjects to create a model ("atlas") of tractography clusters. Perform automatic segmentation of novel tractography datasets (brains) by application of this atlas. Also transfer anatomical information via cluster labels in the atlas.

Progress: Atlas creation and automatic labeling has been performed in high-quality DTI datasets from Susumu Mori. Images showing example segmentation results are below. Work is underway to apply this atlas to segment additional datasets to define regions of interest that may be used in the study of schizophrenia.

Key Investigators:

• Lauren O'Donnell, MIT
• Carl-Fredrik Westin, BWH
• Marek Kubicki, BWH
• Martha Shenton, BWH

Example Results:

Selected anatomical regions, automatically labeled using the cluster atlas in 3 subjects.

Subdivisions of the corpus callosum, labeled using the cluster atlas in 3 subjects.