Mbirn: Segmentation Goals

• Protocol Specific Segmentation (B. Fischl)

For our part, we have agreed to have the multi-echo atlas construction at 1.5T complete within 12 months. In addition, we will begin investigating 3T protocols and segmentation accuracy, and have a preliminary recommendation within 6 months. Finally, we will also continue our comparison of mp-rage and multi-echo FLASH, and have results comparing them in terms of CNR and test-retest reproducibility within 6 months.

• Protocol Neutral Segmentation (S. Pieper)

Oct 2004 - Apr 2005: apply MIRIAD processing tools to MS data (with Charles Guttmann and Lifeng Liu of BWH Center for Neurological Imaging). This will provide additional refinement and validation of the ability to detect white matter lesions for comparison with previous CNI work.
Apr 2005 - Oct 2005: Improved white matter lesion detection procedures will be applied back to the Duke depression data set.

• Facial Masking (S. Pieper)

Oct 2004 - Apr 2005: Revise BIRNDUP application based on feedback from users (Thang at UCI providing feedback being collected by Jonathan Sacks at BWH).
Apr 2005 - Oct 2005: Incorporate any improved face masking techniques (e.g. improved mri_deface) into BIRNDUP.

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