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Objective: To develop methodology that will permit investigators to specify functional MRI regional of interests (fROI) and determine the optimal white matter pathways between the fROIs based on DTI.

Progress: Working path of interest tool at Dartmouth that is currently being tested further. We've had success on mapping out uncinate fasciculus and arcuate fasciculus in a healthy adult. Next step will be to apply the methodology in a larger sample of subjects to verify reliability within and across subjects.

Key Investigators:

• Dartmouth: Andrew Saykin, John West, Robert Roth, Laura Flashman
• Harvard: Dave Tuch, Josh Snyder, Steve Pieper, Gordon Kindlmann

Links:

• Path of Interest Algorithm Development