NA-MIC Brains Collaboration
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Contents
Abstract
This project is not an NCBC collaboration grant, but instead a Continued Development and Maintenance of Software grant. The intent of this application is to update the BRAINS image analysis software developed at the University of Iowa.
Grant#
R01NS050568
Key Personnel
University of Iowa: Vincent Magnotta, PI, Hans Johnson, Jeremy Bockholt, and Nancy Andreasen NA-MIC: Steve Pieper (Isomics)
Funding Duration
05/15/2007-03/31/2010
Projects
There are three main thrusts of this application as outlined below.
Implement an Automated Brain Analysis Pipeline
- BRAINS Automated Pipeline
- Support for Batch Processing
- Visual Review and Verification of Results
- Build GUI using Slicer3 Interface
Validation of Pipeline
- Evaluate MIND MCIC Human Phantom Sample Using Automated Pipeline
- Evaluate of DTI Reliability Across Sites and Platforms
Tools Developed
Here is a list of tools that are being developed as part of this project. A number of these tools have been contributed to the NITRC website. All of the tools are built upon the Slicer3 execution model and therefore will readily plug-in to Slicer3.
- BRAINSFit - Linear fitting of two 3D image sets using a mutual information similarity metric. NITRC Link
- BRAINSDemonsWarp - Non-linear registration of two image sets. This includes the diffeomorphic demons algorithm along with a number of useful enhancements. NITRC Link
- BRAINSMush - Tool to combine T1 and T2 datasets into a composite image. The resulting image is then used to perform brain extraction. NITRC Link
- BRAINSCut - Automated segmentation of subcortical and cerebellar regions of interest using an artificial neural network. NITRC Link
- BRAINSTracer - Tracing tool that uses thge vtkContourWidget for defining a region of interest manually. NITRC Link
- GTRACT - Diffusion tensor analysis and Fiber tracking tool. NITRC Link
- BRAINS Automated Pipeline - Fully automated image analysis pipeline for generation of volumetric measurements. NITRC Link
BRAINS Features
- BRAINS Gallery
BRAINS Surface showing cortical depth
BRAINS Surface showing curvature (ie sulcal and gyral labels)
BRAINS Continuous Tissue Classification
Automated segmentation of Subcortical nuclei using Neural Networks
BRAINS Image Registration using ITK Mutual Information
Lesion identification with FLAIR, T1 and T2 weighted images
Talairach lobar labels
GTRACT DTI fiber tracking
Publications
- Powell S, Magnotta VA, Johnson H, Jammalamadaka VK, Pierson R, Andreasen NC. Registration and machine learning-based automated segmentation of subcortical and cerebellar brain structures. Neuroimage. 2008 Jan 1;39(1):238-47.
