Iowa-NA-MIC-2010-Kickoff

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What

Planning the 3-year course of the Roadmap project

Engineers

• Clement Vachet, DBP engineer, 20% at UNC, working on Iowa DBP, translating NA-MIC technology into use for PREDICT HD
• Mark Scully, DBP engineer at Iowa, Mark & Clement will work closely together, both will attend engineering tcons
• Two major areas: DTI processing and shape analysis
• Marco Ruiz, integration of XNAT with GridWizard to allow XNAT pipeline access to external computational resources

DTI Processing

Goals: Tools for a longitudinal analysis pipeline of changes measured by fiber tractography to identify white matter tracts that have strong co-morbid degenerative timelines compared to subcortical degeneration over time. Enable the use of the advanced DTI processing in NA-MIC within PREDICT HD. Specifically, adapt all NA-MIC tools to work as individual external Slicer modules (in part they already exist, but need further work), as well as combine them into a single Slicer DTI processing wizard.

Steps/Modules:

• process data from raw DICOM data (enhanced DicomToNRRDConverter)
• DTI noise estimation, Rician noise filtering
• DTI QC and motion/eddy current correction (enhanced DTIPrep)
• DTI estimation, property map generation (existing Slicer modules)
• DTI atlas registration (new Slicer module)
• DTI atlas based fiber analysis (new Slicer module)
• DTI atlas computation module (new Slicer module)
• DWI atlas mapping tool (new Slicer module)
• Appropriate reporting of all steps
• DTI processing wizard in Slicer
• Longitudinal DTI analysis module
• Fiber profile measurement/visualization within Slicer

Shape Analysis

Goals: Tools for a longitudinal shape analysis pipeline to identify localized changes in basal ganglia tracts that have strong co-morbid degenerative timelines. Enable the use of the advanced SPHARM & particle shape analysis processing in NA-MIC within PREDICT HD.

Steps/Modules:

• Individual SPHARM tools (exists, needs polishing)
• SPHARM shape summary tool (exists, needs polishing)
• Add support for particle shape analysis (new Slicer module)
• Sun Grid Engine compatibility
  • Target of 2011-01-14: have feasibility shape analysis done to identify outstanding work that needs to be done.

Data

Is the image data already in hand?

• Yes. Over 2900 scan sessions collected. We will need to identify the meaningful subset of this data, get final approval from the Predict Steering Committee for that subset,and then re-deidentify it and post to XNAT for NA-MIC purposes.
• (Target date of 2010-12-10) Identified the FMRI_024 data (77 subjects, 2-3 years longitudinal) as a good candidate data set for collaborative algorithm development platform. This data set has 3 71direction+8B0 DTI data sets, 2 1.0^3 T1 data sets, and a 0.56x0.56x1.4 T2 data set.
  • Will likely need to collect clinical data for shape analysis work that includes: (Age, Gender, Dx, Burdon Score, Motor Score).
  • Will need to re-de-identify all the data to be used here.
  • Will need to run auto-workup for generating Caudate/putamen/hippocampus/thalmus masks.
  • Data exchange will be done through XNAT. including derived data.

Outreach

• Tutorial(s) on the wiki
• Presentations at HBM, Euro-HD.net, HDSA (The Huntington's Disease Society of America) in year 2
• Hands-on teaching event for the DBP scientific community for year 3

Who

• DBP: Hans Johnson, DBP engineer Mark Scully
• Algo: Martin Styner, DBP engineer Clement Vachet
• Eng: Dan Marcus, Jeff Grethe, Marco Ruiz

• Iowa Supporting Guests: Shuhua Wu, Joy Matsui, Ben Rogers, Vince Magnotta

When

• Monday October 25th, 10:30am - 5:30pm
  • 10:30-12:00 Overview of project, and background of PREDICT-HD
  • 12:00- 1:00 Lunch
  • 1:00- 5:30 Working meeting focused on informatics, computations and processing
  • 6:30- 8:30 Dinnner @ One-Twenty-Six
• Tuesday October 26th, 8:00am - 3:30pm
  • 8:00-12:00 Working meeting focused on algorithmic development
  • 12:00- 1:00 Lunch
  • 1:00- 3:30 Finalize timelines
  • 3:30- 5:30 Discuss current limitions of XNAT, and determine how to overcome them
• Wednesday October 27th, 9:30am- 3:00pm
  • GridWizard deployment

Where

The University of Iowa Campus, Meet in W240 Boyd Tower. The conference room is a short distance away from there in the Iowa Center for Translational Science.

Take elevator BW to the second floor, and take two immediate rights. The conference room shares a wall with the BW elevator shaft.

Travel Information

The closest airport to Iowa City is the Cedar Rapids / Eastern Iowa Airport (CID) which is about 20 minutes from the hotel.

Airport Shuttle Services

The easiest way to get from the airport to Iowa City is via one of the shuttle services:

• Airport Shuttle Service (Phone: 1-800-725-8460)
• Airport Express (Phone: 319-626-5466)

Both are the same price and easiest to book before travel. The cost is roughly $60 round trip.

Rental Cars

Rental cars are also available from the Airport. The following companies have desks at the airport

• Avis
  • Website
  • Toll-Free Phone : 1-800-331-1212
  • Local Phone : (319) 366-6418
• Hertz
  • Website
  • Toll-Free Phone : 1-800-654-3131
  • Local Phone : (319) 365-9184
• National and Alamo
  • Website
  • Toll-Free Phone : 1-888-826-6890
  • Local Phone : (319) 363-0249
• Enterprise
  • Website
  • Local Phone : (319) 366-5522

If you have any questions regarding travel, feel free to contact Joe Ekdahl either via e-mail(joe-ekdahl@uiowa.edu) or phone (319-384-3026).

Hotel Information

We reserved a block of hotel rooms at Hotel Vetro at a rate of $139. The group code to get this rate is ITK. These rooms will be held at this rate until October 22.

• Hotel Vetro
  • Phone: 800-592-0355
  • Address: 201 South Linn Street, Iowa City, Iowa 52240

Other hotels that are close to the conference site, University of Iowa, and downtown include:

• Sheraton hotel
  • Phone: 319-337-4058
  • Address: 210 South Dubuque St, Iowa City, IA 52240
• Iowa House Hotel
  • Phone: 319-335-3513
  • Address: 125 North Madison St, Iowa City, IA 52242

Meeting Room

TBD