DBP3:MGH

NA-MIC and MGH Radiation Oncology are collaborating on a Driving Biological Project to provide tools for adaptive radiotherapy in 3D Slicer. We aim to provide the engineering and algorithms needed to perform adaptive radiotherapy, and to do dosimetric comparison studies of the clinical gain that can be achieved in proton-beam therapy for base of skull tumors.

[For more details, see the complete project plan.]

DBP Science

• Goal: Scientific evidence for or against adaptive proton-beam radiotherapy in the base of skull region
• Require: Update literature review
• Recommend: Study to quantify geometry of anatomic differences
• Require: Comparison study of delivered vs. planned dose
• Require: Comparison study of delivered vs. adaptive dose
• Wishlist: Comparison study of IMRT vs. protons

Engineering

See: http://www.na-mic.org/Wiki/index.php/EngineeringRetreat2010

• Pushing CMake module bug fixes upstream

Image Registration

• Goal: Multiple slicer plugins for registration
• Recommend: Experimental evaluation of existing registration methods
• Require: Interactive registration (landmark splines)
• Recommend: Regularized B-splines
• Recommend: B-splines with landmark constraints
• Recommend: B-splines with surface constraints
• Wishlist: Parameter-free registration
• Wishlist: Image-free surface registration
• Wishlist: Parallel optimization

Image Segmentation

• Goal: Slicer plugin for automatic segmentation
• Require: Contour propagation for intra-subject segmentation
• Recommend: Automatic segmentation (atlas-based) for inter-subject segmentation
• Recommend: Automatic segmentation (model-based) for inter-subject segmentation
• Wishlist: Contour interpolation methods for interactive segmentation

Radiotherapy Workflow

• Goal: Reasonably complete workflow, including dose review and comparison tools
• Require: Labelmap that can handle overlapping structures
• Require: Visualization of RT dose (2D, as isodose lines, with legend)
• Wishlist: Visualization of RT dose (3D, w/ Shadie)
• Require: DICOM improvements (CT export, DICOM-RT import/export)
• Require: Compute dose volume histograms
• Recommend: Margin tools
• Wishlist: Visualize dose volume histograms
• Require: Better support for extensions
• Recommend: MRML node for registration
• Recommend: MRML node for patient demographics
• Wishlist: Unevely spaced CT
• Wishlist: Vector field visualization
• Wishlist: DICOM Network I/O

Data

• Goal: 50 cases for inter-subject segmentation
• Goal: 30 cases for intra-subject registration
• Require: New retrospective IRB
• Require: Careful QA of segmentation data
• Require: Validation data for registration studies

Outreach

• Require: Symposium or tutorial at major conference
• Require: Hands-on tutorial at MGH
• Require: On-line tutorials for radiotherapy workflow
• Recommend: User's group meeting at major conference

Personnel

• MGH: Greg Sharp, Annie Chan, George TY Chen, Nadya Shusharina, Rui Li, Ken Westover, Itai Pashtan, John Wolfgang
• MIT: Polina Golland, Michal Depa
• GT: Allen Tannenbaum, Ivan Kolesov
• Isomics: Steve Pieper