Events:Computational Methods for Radiation Oncology

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Date and Location

Date: Thursday, May 5, 2011

Location: Shapiro Boardroom, 70 Francis Street, Boston

Agenda

To brainstorm radonc computational methods between UNC, NA-MIC, BWH.

• 8am: Breakfast
• 8:30-10:30am: UNC -presentations about capabilities of current projects, short term and longer term plans
  • Julian Rosenman PLUNC 18 minutes
  • Gregg Tracton Software for PLUNC, segmentation, registration 10 minutes
  • Stephen Pizer Registration by regression (2 methods), Segmentation via posterior optimization, training probability distributions on s reps and quantile functions, segmentation via correspondence-preserving warps, ant aliasing 23 minutes
  • Sha Chang Nanotube imaging, incl. for IGRT 10 minutes
  • Brandon Frederick Iterative tomographic reconstruction, CTs at treatment time, gpu’s 15 minutes
  • Derek Merck 3D visualization via model-guided rendering, 3D visualization in PLUNC for RTP 15 minutes
  • Ilknur Kabul Texturing of surfaces, onion skins, and cut planes; interpolation of textures 10 minutes
  • Hina Shah Registration of endoscopic cine and CT of throat,fused displays of these two registered sources 8 minutes
  • Ron Alterovitz Planning for brachytherapy with curved needles, FEM software 12 minutes
• 10:30 am: Break
• 10:50am-12pm: NA-MIC/Harvard presentations about capabilities of current projects, short term and longer term plans
  • Slicer3 to Slicer 4, Radiation Therapy support today, and plans for the next year (Steve Pieper) (20 minutes)
  • Head and Neck Cancer NA-MIC DBP (Greg Sharp) (20 minutes)
  • Gynecologic Cancer Brachytherapy Plans (Tina Kapur) (20 minutes)
  • Shadie, shading language for volume visualization(Hanspeter Pfister, Milos Hasan, George Chen, John Wolfgang) (20 minutes)
• 12pm pm: Lunch
• 1pm: Intro of afternoon objectives (Julian Rosenman)
• 1:10pm: What UNC/Boston system combinations ought to be developed -- the Boston perspective (Tina Kapur)
• 1:30pm: What Boston/UNC system combinations ought to be developed -- the UNC perspective (Steve Pizer)
• 2:00-2:45pm: Comments from Kitware about their capabilities relevant to proposed combinations
• 245pm: Break and subgroup formation (e.g., merging surgical and radiation treatment planning system; 3D visualization software for treatment planning; image analysis software for treatment planning)
• 3:00-4pm: Subgroups sketch out mechanics for collaborations
• 4:00-5:0pm: Summary: what we do next?

Agenda items from UNC

1. PLUNC: An open source complete radiation treatment planning system
   1. State of the art, GPU-based dose calculation
   2. Fast IMRT engine
   3. Image registration of unlimited number of images
   4. Manual segmentations in axial, coronal, and sagittal slices
   5. User interface via dials and other continuous controls
   6. Available on many operating systems and computers
   7. Used by ~100 institutions for research
   8. iHERO-compatible
   9. 3D visualization (see item 2)
2. 3D visualization in radiation treatment planning
   1. Integrated within PLUNC
   2. User interface: fully interactive pose and slice control, display entity control
      1. Single-GPU-based
   3. Methods:
   4. MGRview:
      1. Combinations of volume rendering, surface rendering, dose painting, beam outlines and views, …
      2. Object-coordinate based visualization operations for 3D visualization of multiple entities (objects, beams, dose, etc.) supported by texturing (2D and 3D)
      3. Illustration of object shape and position variations across days
3. Image analysis
   1. Skeletal model fitting to anatomic objects
   2. Skeletal model analysis into eigenmodes of variation and principal variances
   3. Segmentation via skeletal models and statistical models of image appearance (Pablo)
   4. Atlas to patient diffeomorphism calculation from corresponding reference object boundary points with correspondence maintenance
   5. Fluid-flow and control-theoretic greyscale diffeomorphism calculation
   6. IGRT from 2D projections to 3D CTs
      1. Registration
      2. CT reconstructions at treatment time therefrom
4. Utilities: Anti-aliased manual segmentations
5. Applications: Endoscopy/CT fusion in head and neck: registration and visualization (early stages)

Agenda items from NA-MIC

1. Works in Progress on RT
   1. DICOM RT Support Roadmap and Head and Neck Cancer Application Summary(Greg Sharp)
   2. Pelvic Applications Summary (Tina)
2. Slicer Roadmap and its relevance to RT

Agenda items from Harvard, MGH

Participants

People who indicated availability on May 5th (http://doodle.com/imkmfnshgmwwtw2a):

1. Julian Rosenman, UNC
2. Stephen Pizer
3. Derek Merck
4. Hina Shah
5. Brandon Frederick
6. Ilknur Kabul
7. Gregg Tracton
8. Sandy Wells
9. James Balter
10. Hanspeter Pfister
11. Ron Kikinis
12. Clare Tempany
13. John Wolfgang
14. Steve Pieper
15. Andrey Fedorov
16. George Chen
17. Tina Kapur

This is the list of invited people:

1. Steve Pizer, UNC
2. Sha Chang, UNC
3. Dave Lalush, UNC
4. Ron Alterovitz, UNC
5. Derek Merck, UNC
6. Ilknur Kaynar-Kabul, UNC
7. Hina Shah, UNC
8. Chen-Rui Chou, UNC
9. Lei Pan, UNC
10. Brandon Frederick, UNC
11. Clare Tempany, BWH
12. Robert Cormack, BWH
13. Greg Sharp, MGH
14. Andrey Federov, BWH
15. Ron Kikinis, BWH
16. Hans Peter Pfister, Harvard
17. George Chen, MGH
18. John Wolfgang MGH
19. Milos Hasan MGH alum/Berkeley
20. Tina Kapur, BWH
21. James Balter, Michigan
22. Gabor Fichtinger, Queens
23. Terry Yoo, NLM
24. Dave Chen, NLM
25. James Deye, NCI
26. Stephen Aylward, Kitware
27. Steve Pieper, Isomics