2012 Winter Project Week:GeometricMetamorphosis
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Estimating the infiltration / recession of pathologies independent of background deformations
Key Investigators
- Kitware: Danielle Pace, Stephen Aylward
- UNC: Marc Niethammer
Objective
- Image registration of longitudinal neuroimaging data of traumatic brain injury (TBI), with the aim of predicting long term outcome and designing treatment plans.
- The geometric metamorphosis registration algorithm jointly estimates global background deformations and local pathology changes. This allows injury changes to be analysed without the impact of background motion.
- Quantification of "infiltrative" versus "displacing" pathology changes may be a clinically-significant biomarker, and is enabled by geometric metamorphosis's separation of total deformation into background and pathology deformations.
Approach, Plan
- Develop and implement voxel-wise estimates of infiltrating versus displacing pathology growth/contraction.
Progress
Delivery Mechanism
This work will be delivered to the NA-MIC Kit as a Slicer extension.
