2014 Project Week:HD 4DShapes

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  Projects List

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  Subcortical evolution in HD

Key Investigators

• Utah: James Fishbaugh, Guido Gerig
• Iowa: Hans Johnson

Project Description

Objective

In the past we have estimated personalized growth models for a small number of HD subjects. For this project we want to estimated models for 84 subjects: 30 CTRL, 16 LOW, 24 MED, 14 HIGH. We want to explore individual models of sub-cortical change, as well as the evolution of white matter. We also want to test the robustness of the estimation by comparing the results estimated forward and backward in time.

Approach, Plan

Sub-cortical change in HD:

• Estimate individual models for all subjects and compare volume extracted from regression.
• Compare models estimated forward and backward in time to explore sensitivity to initial conditions.

White matter evolution:

• Prepare white matter surfaces for regression.
• Experiment on one subject as proof of concept.
• Prep all subject data for estimation -- start estimating models, though it likely won't finish during the project week.

Progress

Summary

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  Estimated forward in time

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  Estimated backward in time.

Caudate volume extracted after shape regression on six subcortical pairs estimated forward in time (left) and backward in time (right).