2010 Winter Project Week DTI Fiber Tract Statistics

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Home < 2010 Winter Project Week DTI Fiber Tract Statistics

Instructions for Use of this Template

  1. Please create a new wiki page with an appropriate title for your project using the convention Project/<Project Name>
  2. Copy the entire text of this page into the page created above
  3. Link the created page into the list of projects for the project event
  4. Delete this section from the created page
  5. Send an email to tkapur at bwh.harvard.edu if you are stuck

Key Investigators

  • Utah: Anuja Sharma, Guido Gerig

Objective

The goal is to understand probabilistic models that can account for the behavior of water diffusion in white matter tracts.


Approach, Plan

The challenge lies in deciphering the underlying probabilistic framework and delineating the relationship between white matter structure and variables like age, gender, physical condition or even high risk for a specific disease. This is done using a command line tool which perform kernel based regression on the DTI data. Casey's functional data analysis pipeline is then applied to this data. The idea is to try out different noise models and statistical measures which are robust to Partial Volume effect and yet give statistically significant results. Our plan for the project week is to try out the complete pipeline for a few datasets and see if this module can be integrated into the Slicer environment.

Progress

The first version of the command line tool is ready. It also incorporates several visualization options which would help in analyzing the best noise models and the best representative statistics to explain the distribution of DTI data along the fiber tract.

References

  • Casey B. Goodlett, P. Thomas Fletcher, John H. Gilmore, Guido Gerig. Group Analysis of DTI Fiber Tract Statistics with Application to Neurodevelopment. NeuroImage 45 (1) Supp. 1, 2009. p. S133-S142